TWO DIFFERENT DOSES OF DEXMEDETOMIDINE IN ATTENUATING SYMPATHOADRENAL RESPONSE TO ENDOTRACHEAL INTUBATION - A COMPARATIVE STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 7
Abstract
BACKGROUND The objective of our study was to determine whether a lower dose (0.6 microgram/kg) of dexmedetomidine is as effective as the usual dose (1 microgram/kg) for attenuating sympathoadrenal response to endotracheal intubation. MATERIALS AND METHODS 90 patients were fixed to undergo elective surgeries under general anaesthesia, were randomly divided into 3 groups. Group Areceived 0.6 microgram/kg of dexmedetomidine, group B received 1 microgram/kg of dexmedetomidine and group C received 10 ml normal saline over 10 minutes before induction. Anaesthesia was standardised in the groups and vital parameters were recorded for up to 10 minutes after intubation. RESULTS At 5 minutes and completion of drug infusion, group B had statistically significant fall in heart rate as compared to group A (17.3% and 27.2% vs. 5.2% and 10.3%). Maximum fall in mean heart rate was observed at 10 minutes after intubation in group A (29.1%) and at completion of drug infusion in group B (27.2%). The maximum fall in SBP in both groups was observed at 10 minutes following intubation, Group C had statistically significant higher values of HR, SBP, DBP, MAP during all time interval following ET intubation. CONCLUSION A lower dose of dexmedetomidine (0.6 microgram/kg) loading dose provides, significantly better attenuation of sympathoadrenal response to endotracheal intubation unaccompanied by transient increase in blood pressure and bradycardia, which is observed at higher dose of dexmedetomidine (1 microgram/kg) loading dose.
Authors and Affiliations
Supriya Kumari Madambikattil Chandrashekharan, Muhammed Shahid Pullat
Keywords
Related Articles
- EP ID EP454558
- DOI 10.18410/jebmh/2018/127
- Views 38
- Downloads 0
SURGICAL OUTCOME OF CHILDHOOD TRAUMATIC CATARACT IN A TERTIARY CARE HOSPITAL
Retrospective study of surgical outcome of sixty two children with traumatic cataract, in the age group of four to fifteen years over a period of two years was done. The study group comprised 41 boys and 21 girls. Stick...
BENIGN LESIONS OF MANDIBLE ON ORTHOPANTOMOGRAM- OUR EXPERIENCE
BACKGROUND Orthopantomography plays a vital role to diagnose mandibular lesions. Odontogenic benign tumours may occur at any period of odontogenesis. Those who develop during first stage of teeth formation do not contain...
MEGALOBLASTIC ANAEMIA WITH MORPHOLOGICAL CHANGES IN MEGAKARYOCYTES- A PROSPECTIVE STUDY
BACKGROUND Megaloblastic anaemia is a nutritional anaemia that results from inhibition of DNA synthesis during red blood cell production. Thrombocytopenia in a case of megaloblastic anaemia may result from many mechanism...
COMPARISON OF ANALGESIC EFFICACY OF INTRAVENOUS REGIONAL ANAESTHESIA WITH LIGNOCAINE AND TRAMADOL VERSUS LIGNOCAINE AND KETOROLAC-A RANDOMIZED CONTROL TRIAL
BACKGROUND Intravenous regional anaesthesia (IVRA, Bier’s block). is a simple regional anaesthesia technique in which analgesia and muscle relaxation are produced by the injection of an adequate volume of local anaesthet...
CONGENITAL MATURE CYSTIC TERATOMA OF PAROTID: A RARE CASE
INTRODUCTION We reported congenital mature cystic teratoma of parotid that presented as a swelling in the left parotid gland region since birth, increasing in size gradually. Teratoma is common neoplasm, but is very rare...