Two pediatric Henoch-Schönlein purpura cases whose severe gastrointestinal hemorrhage treated by cyclophosphamide
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 2
Abstract
Henoch-Schönlein purpura (HSP) is a vasculitis, that involves various organ systems and show different clinical picture. It can be presented with purpura-like skin rash, abdominal pain, arthritis and renal involvement. Rarely, severe skin, gastrointestinal (GIS) and renal involvement occur and can lead to early or late complications. In this paper, it was aimed to report, two HSP children with severe GIS involvement as recurrent intestinal hemorrhage, which did not respond to high dose intravenous steroids, but successfully treated by intravenous cyclophosphamide. One of our patients had also severe necrotic skin lesions that necessitate skin grafting and the other had severe renal involvement as nephrotic syndrome. Intravenous cyclophosphamide may be useful in children with HSP, when severe GIS involvement not respond to high dose steroids. Key words: Henoch-Schönlein purpura, severe system involvement, cyclophosphamide, management
Authors and Affiliations
Aydın Ece, Sevgi Yavuz, İlhan Tan, Ünal Uluca, Duran Karabel
Keywords
Related Articles
- EP ID EP130672
- DOI 10.5798/diclemedj.0921.2013.02.0284
- Views 117
- Downloads 0
Pompe hastalığı: Olgu sunumu
Pompe Hastalığı otozomal resesif olarak kalıtılır ve çoğunlukla asemptomatik taşıyıcıların çocuklarında gözlenir. Glikojen depo hastalığı tip 2 olarak bilinen Pompe hastalığına, lizozomal asit alfa-glukozidaz enzimini k...
Fibromiyalji hastalarında kan vitamin D düzeyleri ve D vitamini tedavisinin etkinliği
Amaç: Fibromiyalji hastalarında D vitamini düzeyini ölçmek, etyopatogenez ile olan ilişkisini belirlemek. Yöntemler: Bu çalışmaya; 2012 yılında Haziran ve Aralık ayları arasında Metin Sabancı Baltalimanı Kemik Hastalı...
Comparison of hair and nail ethyl glucuronide concentrations
Objective: Alcohol abuse remains to be an important problem in the world. In forensic medicine practice, alcohol and its metabolites should be detected in the body in order to determine whether a person has taken alcoho...
Clinical Outcomes of Penile Prosthesis Implantation Surgery
Objective: We aimed to evaluating the outcomes of inflatable penile prosthesis implantations and partner satisfaction. Methods: Data of 52 patients who underwent penile prosthesis implantation in single center betwee...
Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu
Amaç: Akne vulgaris adölesan ve genç erişkinleri etkileyen en yaygın deri hastalığıdır. Çinko insanlar için esansiyel bir elementtir. Bazı çalışmalarda serum çinko seviyeleri ve akne vulgaris arasında bir ilişki rapo...