Two pediatric Henoch-Schönlein purpura cases whose severe gastrointestinal hemorrhage treated by cyclophosphamide
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 2
Abstract
Henoch-Schönlein purpura (HSP) is a vasculitis, that involves various organ systems and show different clinical picture. It can be presented with purpura-like skin rash, abdominal pain, arthritis and renal involvement. Rarely, severe skin, gastrointestinal (GIS) and renal involvement occur and can lead to early or late complications. In this paper, it was aimed to report, two HSP children with severe GIS involvement as recurrent intestinal hemorrhage, which did not respond to high dose intravenous steroids, but successfully treated by intravenous cyclophosphamide. One of our patients had also severe necrotic skin lesions that necessitate skin grafting and the other had severe renal involvement as nephrotic syndrome. Intravenous cyclophosphamide may be useful in children with HSP, when severe GIS involvement not respond to high dose steroids. Key words: Henoch-Schönlein purpura, severe system involvement, cyclophosphamide, management
Authors and Affiliations
Aydın Ece, Sevgi Yavuz, İlhan Tan, Ünal Uluca, Duran Karabel
Keywords
Related Articles
- EP ID EP130672
- DOI 10.5798/diclemedj.0921.2013.02.0284
- Views 129
- Downloads 0
The effect of serum 25(OH) vitamin D on hemogram parameters
Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin. In general, vitamin D is known to be associated with rickets, but the studies show that vitamin D also acts on tissues and cell...
Candida albicans dışı mayaların tanımlanmasında VITEK 2 YST kart ile API 20C AUX sisteminin karşılaştırılması
Amaç: Bu çalışmada çeşitli klinik örneklerden soyutlanan Candida albicans dışı mayaların tür düzeyinde tanımlanmasında VITEK 2 YST kart (bioMérieux, Fransa) kullanılarak elde edilen sonuçların API 20C AUX (bioMérieux,...
Liken planuslu 165 hastanın klinik ve demografik özellikleri
Amaç: Liken planus (LP) deri, muköz membranlar, tırnaklar ve saçlı deriyi tutabilen papuloskuamöz inflamatuar bir hastalıktır. İnsidansı coğrafik bölgelere göre farklılık göstermektedir. Bu çalışmada kliniğimizde LP t...
Single center experience in endovascular aortic repair: review of technical and clinical aspects
Objective: The aim of this study is sharing of our endovascular aortic repair experiments in patients with high risk for surgery and contributing to literature with comparing previous report according to mortality compl...
Seftriakson kullanımı sonucu gelişen toksik epidermal nekrolizis: Bir olgu sunumu
Toksik epidermal nekrolizis (TEN) nadir görülen, hayatı tehdit eden, ciltte epidermis dermis ayrışması yapan ve haşlanmış deri görünümü veren, genellikle ilaç kullanımı ile ilişkili bir klinik durumdur. Acil servise 71...