Two Side Effects of Sutent Therapy in Renal Cell Carcinoma: A Case Report
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 4
Abstract
Introduction Renal cell carcinoma (RCC) has known as the most frequent urological malignancy among adults, which occured mostly among male patients. Sunitinib malate (SUTENT<sup>®</sup>, Pfizer Inc., New York, NY, USA) is an oral, multitargeted tyrosine kinase inhibitor (TKI) which acts on VEGF receptors 1–3. Herein, we have presented two simultaneous adverse effects (nail changes and erythematous lesions over the knuckles) of 26-year-young woman with a high risk RCC during the sunitinib therapy. Case Presentation Our patient was a 26-year-young woman, who has undergone left radical nephrectomy in December 2013. Microscopic pathological analysis has shown a 40 mm clear cell carcinoma of grade 2. She has started on target therapy with sunitinib, at over 3 months of TKI Sutent 50 mg four weeks on and two weeks off in this drug. We have seen, nails changes and erythematous lesions over the knuckles. After decreasing the dosage of the drug to 12.5 mg four weeks on and two weeks off the severity of lesions have decreased and subside the complaints of patients. Conclusions Sunitinib therapy could have different side effects among patients. We have not known that a benign side effect could affect a female patient like discoloration despite, or not. This matter that you had not any interference for its treatment, but it has exited so we must try to know more about it.
Authors and Affiliations
Mehrdad Payandeh, Edris Sadeghi, Masoud Sadeghi
Keywords
Related Articles
- EP ID EP237359
- DOI 10.5812/ijcm.4040
- Views 73
- Downloads 0
Association Between Cytochrome 1B1*3 Polymorphism and the Breast Cancer in a Group of IranianWomen
Background: As a hormone-dependent cancer, estrogen is involved in the development of breast cancer. CYP1B1 belongs to the P450 superfamily of enzymes and is involved in the metabolism of estrogen. The present study inve...
Clinical Outcome and Prognostic Factors for Nasopharyngeal Carcinoma: A Single Institution Study in Iran
Background Evidence about survival of the patients with nasopharyngeal cancer is scant in our region and the aim of the current study was to determine clinico-pathological factors...
Seroprevalence of Cytomegalovirus Antibodies and Primary Infection amongWomen and Infants in Iran: A Meta-Analysis
Background: Seroprevalence of Cytomegalovirus infection varies between 40% and 100% worldwide. Different studies carried out in Iran indicate this variation in this country. It is important to estimate the total infectio...
Trends in the Incidence of Cancer in Iran (2003 - 2009)
Background Cancer is a leading cause of death throughout the world. Increasing life expectancy and aging population are important factors for increasing cancer incidences in devel...
Comparison of Three Clinical Models for Estimating the Risk of Endometrial Cancer in Post-Menopausal Women with Abnormal Vaginal Bleeding
Background: Given the prevalence of abnormal post-menopausal bleeding and the importance of its early examination for ensuring the timely diagnosis of any malignancies, the present study was conducted to investigate uter...