TWO WAVELENGTHS DEPENDENT SPECTROPHOTOMETRIC METHODS FOR QUANTITATIVE ESTIMATION AND VALIDATION OF OXFENDAZOLE IN PRESENCE OF ITS ALKALI-INDUCED DEGRADATION PRODUCT: A COMPARATIVE STUDY
Journal Title: Innoriginal: International Journal Of Sciences - Year 2017, Vol 4, Issue 4
Abstract
Four simple, accurate, selective, reproducible and sensitive spectrophotometric methods, each method based on the selection of two wavelengths, have been developed and validated for the determination of oxfendazole in the presence of its alkali-induced degradation product without preliminary separation. These methods include (A) dual wavelength method at 291.6 and 304.9 nm, (B) Q-analysis method at 275.5 and 292 nm, (C) simultaneous equation method at 292 and 299 nm and (D) absorbance ratio method at 275.5 and 292 nm. These methods were validated and successfully applied for the determination of oxfendazole in Unifendazole® suspension. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level, and no significant difference was observed regarding accuracy and precision.
Authors and Affiliations
AHMED W. MADKOUR, FATHY M. SALAMA, KHALID A. M. ATTIA, AHMED A. MOHAMAD, RAGAB A. SAID
Keywords
Related Articles
- EP ID EP431227
- DOI -
- Views 161
- Downloads 0
FORMULATION AND IN-VITRO EVALUATION OF METFORMIN HYDROCHLORIDE LOADED MICROSPHERES FOR ORAL CONTROLLED RELEASE
Biodegradable microspheres may develop improved drug delivery system to gastrointestinal tract, for treatment of Diabetes. Metformin hydrochloride have the ability to produce thus effect for extended period.The Objective...
A COMPARATIVE STUDY OF GUGGULU (COMMIPHORA MUKUL) COATED KSHARA SUTRA AND SHALA (SHOREA ROBUSTA) COATED KSHARA SUTRA ALONG WITH STANDARD KSHARA SUTRA IN THE MANAGEMENT OF BHAGANDARA W.S.R. U.C.T.
Standard Apamarga ksharasutra is used successfully in the management of Bhagandara by researcher. But Snuhi latex having a ve ry little amount of it is collected after the incision of stem, requires fresh latex in ever c...
TWO WAVELENGTHS DEPENDENT SPECTROPHOTOMETRIC METHODS FOR QUANTITATIVE ESTIMATION AND VALIDATION OF OXFENDAZOLE IN PRESENCE OF ITS ALKALI-INDUCED DEGRADATION PRODUCT: A COMPARATIVE STUDY
Four simple, accurate, selective, reproducible and sensitive spectrophotometric methods, each method based on the selection of two wavelengths, have been developed and validated for the determination of oxfendazole in th...
ANTIOXIDANT EFFECTS OF METHANOLIC STEM-BARK EXTRACT OF PTEROCARPUS ERINACEUS ON INDOMETHACIN-INDUCED ULCER IN ALBINO RATS
Objective: The antioxidant effects of methanolic stem-bark extract of Pterocarpus erinaceus on indomethacin-induced ulcer in albino rats was studied. Methods: Phytochemicals in the bark extract were qualitatively and qua...
A PROMISING APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY BY SELF EMULSIFYING DRUG DELIVERY SYSTEM: A BRIEF REVIEW
Objective: The formulation of self-emulsifying drug delivery system of drugs is to enhance the solubility and bioavailability. More than 40% of available drugs exhibit poor water solubility, resulting in unsatisfactory o...