Type 1 Diabetes Mellitus: Cellular and Molecular Pathophysiology at A Glance
Journal Title: Cell Journal(Yakhteh) - Year 2018, Vol 20, Issue 3
Abstract
Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing pancreatic beta-cells leads to increased blood sugar levels. Both genetic and environmental factors play a part in the development of T1DM. Currently, numerous loci are specified to be the responsible genetic factors for T1DM; however, the mechanisms of only a few of these genes are known. Although several environmental factors are presumed responsible for progression of T1DM, to date, most of their mechanisms remain undiscovered. After several years of hyperglycemia, late onsets of macrovascular (e.g., cardiovascular) and microvascular (e.g., neurological, ophthalmological, and renal) complications may occur. This review and accompanying figures p rovides a n o verview o f t he e tiological f actors f or T 1DM, its pathogenesis at the cellular level, and attributed complications.
Authors and Affiliations
Bahar Saberzadeh-Ardestani, Razieh Karamzadeh, Mohsen Basiri, Ensiyeh Hajizadeh-Saffar, Aisan Farhadi, A. M. James Shapiro, Yaser Tahamtani, Hossein Baharvand
Keywords
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- EP ID EP468831
- DOI 10.22074/cellj.2018.5513
- Views 215
- Downloads 0
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