Type-2 Diabetes Mellitus and Its Risk of Coronary Heart Disease
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2017, Vol 1, Issue 3
Abstract
Coronary artery disease (CAD) is an emerging health problem in India, various risk factors contributing to increase prevalence of CAD in different age groups. Hypertension, diabetes mellitus, smoking and dyslipidemia are the most common causes of coronary artery disease (11). The high incidence of risk factor for coronary disease in elderly individuals is diabetes mellitus. In early patients aging is associated with change in beta cell function and insulin resistance that predisposes to disease. Diabetes Mellitus is one of the most common endocrine disorders. A present world prevalence of DM is around 4% and in 2025 is expected to be around 5.4% (Parks textbook PSM 2000), in India the prevalence of type-2 DM is 3.8%. Currently this disease affect over 40.9 million in India and 422 million peoples in worldwide, a number that is expected 57 million in India and double in worldwide upto 2025. Material and Methods: The study was conducted in the dept. of Medicine in collaboration with central clinical laboratory. A total of 200 patients were included in the study with the history of diabetes. Out of 200 patients 100 were diabetic and having CAD group and 100 were control i.e. diabetic without history of CAD. Result: Associated risk factors for cardiovascular disease were, smoking, hypertension and dyslipidemia and Hypercholesteremia. 55% diabetic with CAD and 34% diabetic without CAD were smokers. 38% of diabetic with CAD and 17% of diabetics were having hypercholesteremia or dyslipidemia. Mean total cholesterol in diabetic with CAD group was 225± 21.45 and in diabetic group was 214 ± 16.24. Mean systolic blood pressure in diabetic with CAD and diabetic without CAD was 134 ± 6 and 129± 5 respectively. There was a significance of smoking, dyslipidemia, hypertension and mean systolic blood pressure levels in patients with CAD. In our study no significant association of BMI was observed in CAD and non-CAD group. Conclusion: On the basis of results we concluded that DM is associated with an increased risk of cardiovascular death and a higher incidence of cardiovascular disease including coronary artery diereses (CAD), congestive heart failure; increase in the prevalence of overweight and was responsible for the recent increase in the prevalence of Non-insulin dependent diabetes mellitus. Hyperglycemia and hypertension in men and diabetic dyslipidemia in women are major risk factors amenable to more aggressive treatment. Key words: CAD, DM, CHD, CCL, T2D.
Authors and Affiliations
Dr. Mahendra M. Sawarkar
Keywords
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