Ultrasonic and Microwave effects on the Benzamide/Sulfuryl Chloride mediated benzoylation of Benzene derivatives under Vilsmeier-Haack conditions
Journal Title: Chemical Methodologies - Year 2017, Vol 2, Issue 2
Abstract
Benzamide/ Sulfuryl Chloride (SO2Cl2) reagent has been developed as a Vilsmeier- Haack(VH) reagent for benzoylation of aromatic compounds under conventional and ultrasonic sonication (US) and microwave (MW) conditions. Benzoylation is much more competent and faster than analogous VH ((Benzamide/ POCl3) or (Benzamide/SOCl2)) reagents and afforded benzoyl derivatives in fairly good yields. Reaction times are moderately less than those observed with [Benzamide/ POCl3] and (Benzamide/SOCl2) reagents. Reaction times are far less in microwave assisted (MWAR) reactions than ultrasonically assisted (USAS) reactions , which in turn are less than the conventional method with a decreasing trend: MWAR (seconds) << Sonication (minutes) << conventional (hrs). Highly remarkable rate accelerations in MW assisted reactions are attributed to bulk activation of molecules, while US assisted reactions could be accounted for cavitation effects.
Authors and Affiliations
Marri Venkateswarlu, Mukka Satish Kumar, Chinna Rajanna Kamatala, Purugula Venkanna, Pondichery Kuppuswamy Saiprakash
Keywords
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- EP ID EP252648
- DOI 10.22631/chemm.2017.97065.1010
- Views 101
- Downloads 0
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