Understanding Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Critical Update in Development of New Approaches
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1
Abstract
ABSTRACT Cancer Stem Cells (CSCs) have an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). HNSCC is considered as one of the major health problems throughout the world. These self-renewing cells are responsible for resistance to conventional anti-cancer therapy. CSCs have the ability of cancer recurrence; metastasis and can form a heterogeneous tumour. The idea of 'CSCs' has led the scientific community to a new era in the field of research and possibly effective treatment modalities for cancer in the future. This paper aims primarily to review the recent advancements made in the use of stem cells in the treatment of cancer. Secondly, this review presents a discussion on the consideration of CSCs being the backbone in the development of cancer and, precisely the role played by the CSCs in carcinogenesis and its outcome leading to development of possible cancer treatment in the future. Medical databases including Pubmed Central, Google Scholar, Scopus, Copernicus, Science Direct, etc., were used to find all relevant articles related to HNSCC and its relation with CSCs, various mechanisms and therapeutic approaches. Various therapeutic approaches have been employed for the management of HNSCC such as surgical method, chemotherapies and radiotherapies and combinations or formulations of different drugs, but in most cases complete cure has been a failure. This is mostly because the CSCs escape such therapies. However, recent developments have led to the use of targeted therapy such as targeting cell surface markers or signalling pathways, targeting micro environment or blocking epithelial mesenchymal transition, immunotherapy and other approaches as well, leading to the complete eradication of CSCs in HNSCC successfully. Thus, this review presents a better understanding of CSCs and its mechanism of action for development of new treatment modalities.
Authors and Affiliations
Shubha Ranjan Dutta, Deepak passi, Dhruv kacker, Mansi Atri
Keywords
Related Articles
- EP ID EP507323
- DOI 10.7860/JCDR/2018/30444.11096
- Views 37
- Downloads 0
Outbreak of Dengue Fever in Bundelkhand Region: A Tertiary Care Hospital Study Report
ABSTRACT Introduction: Dengue is most widely spread mosquito-borne viral disease which is a major public health threat globally. The incidence of dengue fever is increasing year after year with morbidity and mortality in...
Role of Salivary Electrolytes in Prevalence of Dental Caries among Diabetic and Non-Diabetic Adults
ABSTRACT Introduction: Diabetes mellitus has been linked with an increased risk of caries, gingivitis and periodontal disease. Dental caries is more prevalent and even more severe in diabetic patients than non-diabetics....
Spink1 Mutation in Idiopathic Recurrent Acute Pancreatitis- A Pilot Study
ABSTRACT Introduction: Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP) are labeled as idiopathic when no identifiable factors are found. The identification of genetic mutations associated with pancreatit...
Opportunistic Microorganisms in Oral Cavity According to Treatment Status in Head and Neck Cancer Patients
Introduction: Cancer patients receiving chemotherapy and/ or radiation therapy are prone to many predisposing factors like immunosuppression, imbalance in the oral flora, hyposalivation and local tissue damage. Therefore...
Shear Bond Strength of Metal Brackets to Zirconia Following Different Surface Treatments using a Universal Adhesive
ABSTRACT Introduction: As there is increase in demand of orthodontic treatment by adult patients, bonding of orthodontic brackets to dental restoration surfaces is now a common necessity because most adult patients have...