Unilateral segmental Darier disease following Blaschko lines: A case report

Journal Title: Nasza Dermatologia Online - Year 2017, Vol 8, Issue 3

Abstract

Darier disease is an autosomal-dominant disorder of keratin production which leads to a loss in epithelial adhesion and abnormal keratinization. The clinical correspondence is keratotic papules grouped in sebaceous areas of trunk, scalp, forehead and flexures. It is a rare disease and the variant focused on here of unilateral segmental distribution following the lines of Blaschko is rarer still, considering the fact that this presentation counts for only 10% of this already uncommom disease and with only 40 cases being reported in English medical literature. Mutation in this gene is expressed in the skin and brain. The treatment of Darier disease can be challenging and is often difficult and sometimes unsatisfactory. Systemic retinoids are considered the drug of choice for treating Darier disease. However, their use is limited by potential side effects. We described the case a metalworker male with unilateral segmental Darier disease following Blaschko lines and we review the literature on this subject.

Authors and Affiliations

César Bimbi, Piotr Brzeziński Brzeziński

Keywords

Related Articles

Digital Fibromas. Report of three cases

Digital fibroma is a rare benign lesion that usually occurs during the first 2 years of life. It can be multiple, but it is usually a single lesion. If it grows large enough it can cause joint deformities or interfere wi...

Painful bruising syndrome: A case report

Painful bruising syndrome or Gardner-Diamond syndrome is characterized by an auto erythrocyte sensitization syndrome. We report, here a new case of painful bruising syndrome in a woman with no psychiatric disorders. A 29...

Pseudokaposi's sarcoma: a diagnostic dilemma

Acroangiodermatitis of mali also called as pseudokaposi s sarcoma is a very rare, benign condition which clinically presents as purple-colored patches, plaques or nodules, mostly on the extensor surfaces of lower extremi...

Download PDF file
  • EP ID EP286964
  • DOI 10.7241/ourd.20173.93
  • Views 128
  • Downloads 0

How To Cite

César Bimbi, Piotr Brzeziński Brzeziński (2017). Unilateral segmental Darier disease following Blaschko lines: A case report. Nasza Dermatologia Online, 8(3), 326-328. https://europub.co.uk/articles/-A-286964