Unique Localization of Bovine Viral Diarrhea Virus Non-Structural NS4B Protein in Infected Cells
Journal Title: JOURNAL OF ADVANCES IN AGRICULTURE - Year 2016, Vol 6, Issue 1
Abstract
Bovine viral diarrhea virus (BVDV), an important pathogen infecting ruminants, has 2 biotypes: cytopathic (cp) and noncytopathic (ncp), which are related to the onset of disease. The viral replication complex is composed of viral non-structural (NS) proteins, raising the possibility that NS protein(s) play a role in viral biotypes. To gain insight into this possible role, we analysed the intracellular localization of each NS protein in both cp and ncp virus-infected cells, and found that NS4B protein, a possible anchor protein of the viral replication complex, showed a unique dotted localization pattern that markedly merged with an endoplasmic reticulum marker, unlike other NS proteins, although there was no difference in the localization of NS4B protein between the 2 biotypes.Â
Authors and Affiliations
Yuto Suda, Daisuke Yamane, Muhammad Atif Zahoor, Yassir Mahgoub Mohamed, Shin Murakami, Kentaro Kato, Taisuke Horimoto, Hiroomi Akashi
Keywords
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- EP ID EP652446
- DOI 10.24297/jaa.v6i1.5396
- Views 169
- Downloads 0
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