Unique UV Spectrophotometric Method For Reckoning of Aceclofenac in Bulk and Pharmaceutical Dosage Forms Using Hydrotropic Agents
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 5
Abstract
Aceclofenac, chemically, a phenylaceticacid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins. In present work, a selective, specific, sensitive and economical hydrotropic agent assisted spectroscopic method using 1M sodium bicarbonate and 1M urea (50:50% v/v), as hydrotropic agent; to increase the solubility of poorly water-soluble Acelofenac, has been developed for the estimation of Aceclofenac in Bulk and its pharmaceutical dosage forms. An absorption maximum was found to be at at273.6nm where sodium bicarbonate, urea and other excipients did not show any absorbance above216nm and thus no interference in the estimation. Aceclofenac was obeyed Beer’s law in the concentration range from 10-60 µg / ml. Proposed method was validated according to ICHguidlines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values with correlation coefficient of 0.9997. The percentage recovery of Aceclofenac ranged from 99.8 to 100.2 % in pharmaceutical dosage form. Results of the analysis for accuracy, precision, LOD, LOQ and were found to be satisfactory. The proposed method is simple, rapid and suitable for the routine quality control analysis. Keywords: Aceclofenac, Hydrotropy, UV Spectrophotometry
Authors and Affiliations
Srinath Nissankararao, Anil Kumar. A, Ramadevi Bhimavarapu, Renuka. K, Anusha. A
Keywords
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