Unsuspected primary renal urothelial carcinoma with squamous differentiation in a background of long standing renal calculi: A case report
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2018, Vol 4, Issue 1
Abstract
Introduction Primary upper urinary tract tumors are quite uncommon Most of these are malignant epithelial tumors out of which 90 are urothelial carcinomas The majority of patients are male and elderly Long standing renal calculus is a common etiology Insidious onset of disease lack of specific signs and symptoms and the inability of routine radiological investigations to detect tumour areas lead to delay in diagnosisAims and Objectives to study the histomorphological features of incidental primary urothelial carcinoma of kidney with squamous differentiationMaterials and Methods formalin fixed hematoxylin and eosin stained sections of a nephrectomy specimen submitted in the Pathology department of SN Medical College Agra were observed microscopically and findings were notedResult A nephrectomy specimen was submitted for histopathological examination Grossly kidney was severely hydronephrotic with dilated calyces and multiple calculi No tumour or growth was noted Histology revealed primary urothelial carcinoma with squamous differentiation Vascular and perineural invasion was also noted Hilum showed presence of urothelial carcinoma in situ with dysplasia Extensive areas of necrosis were also seenConclusion In patients presenting with long standing renal calculi and poorly functioning kidney urothelial malignancy should be suspected and radiological investigations like CT scan should be done pre operatively Squamous differentiation is common in urothelial carcinomas and is associated with aggressive diseaseKeywords Urothelial carcinoma Nonfunctioning kidney Squamous differentiation
Authors and Affiliations
Shikha Prakash, Asbah Shams
Keywords
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- EP ID EP482914
- DOI 10.18231/2455-6793.2018.0010
- Views 77
- Downloads 0
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