Unusual Alveolar Pattern in Node Based Diffuse Large B-cell Lymphoma
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 1
Abstract
Diffuse Large B-cell Lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma worldwide. We present a case of 45 year old male patient presenting with swelling in right side of the neck since 6 months. A cytological aspirate of the lymph node suggested possibility of malignancy and excision biopsy was advised. Histopathology revealed a well-developed alveolar pattern with nests of dyscohesive large round tumour cells separated by delicate fibrovascular septae. Tumour cells were positive for CD45, CD20 and BCL-6 and negative for CD3, CD 5, CD 10, BCL-2, Desmin, Chromogranin, Synaptophysin and S-100. Based on histopathology and immunohistochemical findings, final diagnosis of DLBCL, NOS was given. The case is presented to highlight an unusual morphological alveolar growth pattern in DLBCL.
Authors and Affiliations
Archana C Buch, Jay Y Sheth, Sunita A Bamanikar, Aditi A Pandey
Keywords
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