Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 0
Abstract
Diabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that cyclooxygenase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids, via up-regulation of COX-2, interferes with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular tone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus.
Authors and Affiliations
Zsolt Bagi, Nóra Erdei, Z Papp, I Edes, Akos Koller
Keywords
Related Articles
- EP ID EP159880
- DOI -
- Views 81
- Downloads 0
Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats.
Aluminium, is a trace element available in the Earth's crust naturally and has a toxic potential for humans. It has been suggested as a contributing factor in the pathogenesis of Alzheimer's disease. β-Adrenoceptor block...
Effects of different priming doses of fentanyl on fentanyl-induced cough: a double-blind, randomized, controlled study.
Background: Fentanyl-induced cough is not an uncommon phenomenon during the induction of general anesthesia. A preliminary randomized controlled study was designed to observe the effects of different priming doses of fen...
Peripheral antinociception and anti-edematogenic effect of a sulfated polysaccharide from Acanthophora muscoides.
Background: Sulfated polysaccharides from red marine algae have presented a variety of potentially therapeutic biological effects, however, their antinocicpetive and anti-inflammatory properties are not well understood....
NMDA and AMPA receptors are involved in the antidepressant-like activity of tianeptine in the forced swim test in mice.
It is known that tianeptine exhibits antidepressant-like activity. Its influence on the glutamatergic system is also known, but the mechanisms involved in this activity remain to be established. The aim of this study was...
Beneficial role of telmisartan on cardiovascular complications associated with STZ-induced type 2 diabetes in rats.
We studied the effect of an eight-week treatment with telmisartan (5 mg kg(-1)day(-1)) on cardiovascular complications that are associated with type 2 diabetes in a neonatal rat model. Type 2 diabetes was induced by the...