Update onarsenic Exposure Link inCancer
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 6
Abstract
Acute arsenic poisoning is uncommon, but inorganic arsenic exposure is worldwide. The highest affected areas are Bangladesh and West Bengal. Ground water most often gets contaminated due to agriculture and mining activities. Contributory factors include arsenic in the drinking water and through food. Inorganic arsenites(arsenic(III),in drinking water have a much higher acute toxicity than organic arsenates(arsenic(V).Arsenic interferes with cellular longevity by allosteric inhibition of essential metabolic enzyme pyruvate dehydrogenase (PDH) complex, which catalyzes the oxidation of pyruvate to acetyl-CoA by NAD.The common symptoms of arsenic poisoning include headache confusion, severe diarrhea, anddrowsiness. Acute symptoms may include diarrhea, vomiting, vomiting blood, blood in urine, and convulsions, Body organs affected are the lungs,skin, kidneys and liver, and eventuallycoma and death. Arsenic increases the risk of cancer, heart disease, stroke, chronic lower respiratory diseases and diabetes. Arsenic may be measured in blood, urine hair, and finger nails. DMSA monoesters are promising antidotes for arsenic poisoning.
Authors and Affiliations
Murtaza Mustafa, RK. Muniandy, EM. Ellzam, HM. Iftikar, K. Fairrul, MK Nang, AM. Sharifa
Keywords
Related Articles
- EP ID EP600493
- DOI 10.9790/0853-16060196101.
- Views 78
- Downloads 0
Study on Effect of Steroid on Calcium and Vitamin D in Children with Nephrotic Syndrome in a Tertiary Care Hospital in Jharkhand
Minimal Change Disease is the leading cause of childhood Nephrotic Syndrome . Therefore in nephrotic syndrome, most children beyond the first year of life will be treated with corticosteroids .Children with Nephrotic syn...
Evaluation of Hyperbilirubinemia As A Diagnostic Marker for Acute Appendicitis
Background and Objectives: Acute Appendicitis is the commonest general surgical emergency, which needs early surgical intervention, to improve the outcome. The rate of misdiagnosis of appendicitis and the rate of appendi...
Analysis on Reliability Evaluation in Power System
Assessment of reliability performance in each power systems has to be performed in a cost-benefit structure. The model, yet, a time-consuming task, particularly for the systems which includes a huge count of feasible con...
Review on the surgical management of pilonidal sinus
.
Sites of Infections and choice of antimicrobial drugs in acute leukemia in Indian Children
In this study children with acute leukemia were evaluated for the incidence and sites of infection, correlation with absolute neutrophil count, causative organisms and to standardize the initial empirical anti microbial...