Uric Acid as a Biomarker of Metabolic Syndrome in Sudanese Adults
Journal Title: International Journal of Biochemistry & Physiology - Year 2018, Vol 3, Issue 4
Abstract
Serum uric acid (SUA) is considered as a component and a marker of metabolic syndrome (MetS). Our aim is to investigate the prevalence of hyperuricemia and its relationships to MetS and its components such as hypertension (HTN), glucose intolerance, obesity and hyperlipidemia among Sudanese population. Method: This is a descriptive cross sectional study, held in Khartoum State, Sudan. The study was performed with a sample of 219, adults, attending the clinics set by the Sudanese Society of Hypertension on the occasion of the International day of hypertension from 2015 to 2016. Using World Health Organization WHO) definition, direct measurements were obtained for metabolic syndrome components; anthropometric screenings included: measurement of height, weight, and body mass index (BMI). The clinical and biochemical screenings included: measurement of blood pressure (BP) and determination of fasting lipid profile, glucose concentrations and serum uric acid. Results: This study enrolled 219 participants aged 18 – 75 year. MetS prevalence was 25.1 % among the entire group, (41.8% males, & 58.1% females). Hyperurecemia was detected in (41.1%) among the study group (52.2 % males, 47.7% females P >0.05). 60% of the MetS cases were found to suffer from Hyperurecemia. (P < 0.01). In the overall group, SUA concentrations ranged from 3.0 – 12.0 mg/dl, with a mean of 6.0 ±1.7 mg/dl. Hyperurecemia was significantly positively correlated with BMI (r=.226, p= .001), triglyceride (r= .247, p=.000), and cholesterol (r= .184, p=.007). Conclusion: Hyperuricemia was highly prevalent among Sudanese population. Additionally, for those with hyperuricemia, the odds ratios (95% CI) for metabolic syndrome were 3.61 (95% CI, .591~ .749) and for fasting blood glucose 0. 478 (95% CI, .392~.593). SUA can be considered as a better predictor of metabolic syndrome than fasting glucose, though not as good as hyperlipidemia and obesity.
Authors and Affiliations
Elbadawi N
Keywords
Related Articles
- EP ID EP396450
- DOI 10.23880/ijbp-16000137
- Views 71
- Downloads 0
Expression of Wnt Genes in Echinaster Sepositus Arm Regeneration
Reparative regeneration is defined as the replacement of lost adult body parts and is a phenomenon widespread yet highly variable among animals, and thus thought to have evolved several times. This raises the question of...
Investigation of the Effects of Boron on Leucocyte Functions and Formed Free Radical Status in Endotoxin-Mediated Inflammation
Endotoxins are lipopolysaccharides which make up some part of the cell walls of gram negative bacteria. Endotoxemia is one of the most important mechanisms in the generation of inflammation. Inflammation is a powerful ph...
The Relationship between the Anti-Sperm Antibodies and Immunologic Infertility
Infertility is an outbreak phenomenon in the world and the outbreak of it is increasing. The anti-sperm antibodies (ASA) are one of the causes of infertility and the resultant infertility of them is called immunologic in...
Investigation Effect of Free Radical Generated from Cement Dust on Antioxidant Enzymes Activities on Cement Factory Workers
This study investigated effects of cement dust on antioxidant enzymes activities of Obajana Cement factory workers. Sixty (60) workers in different units/sections exposed to cement dust and controls (unexposed to cement...
Pre-Steady-State Kinetics of the Binding and Hydrolysis of mant-cGMP by Phosphodiesterase-5
Phosphodiesterase-5 (PDE5), receptor for the drugs sildenafil (Viagra ), vardenafil (Levitra), and tadalafil (Cialis), selectively hydrolyzes the second messenger cGMP. However, its hydrolytic mechanism is unknown. Th...