Uric acid in Type 2 Diabetes mellitus with nephropathy
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 3
Abstract
Introduction: Uric acid is an important antioxidant that contributes for around 60% of free radical scavenging capacity of serum. Its role has been controversial in type 2 diabetes mellitus. Earlier studies have reported that renal disease leads to elevation of uric acid in DM, but recently high uric acid levels are reported to be risk factor for the development of diabetes mellitus. Aim of our study is to compare uric acid in type 2 DM with renal disease with non-diabetics and also to compare its levels among patients in different stages of diabetic nephropathy. Methodology: The case control study was conducted in medical college hospital in coastal Karnataka. Data of serum uric acid, renal profile and demographic profiles of 89 type 2 diabetes mellitus patients was collected from the clinical biochemistry laboratory in the year 2016. Data of 80 non-diabetic controls was taken. Transasia XL-640 was used for the estimation.Estimated GFR (eGFR) was calculated using MDRD formula. Results: We found an elevation in uric acid and creatinine levels, extremely significantly lower eGFR in diabetics (P = 0.0195, P=0.0078 and P =0.0001respectively).Odd’s ratio was 3.128 between uric acid and diabetic nephropathy. A highly significant (P< 0.0016) differences was observed in uric acid levels among patients of different stages of diabetic nephropathy. Conclusion: Hyperuricemia was found in diabetic nephropathy patients. There was a significant difference in uric acid was observed among different stages of nephropathy. However causal relationship is inclusive. Prospective studies need to be designed with a serial monitoring of uric acid, GFR and microalbunuria in diabetics till the development of nephropathy to establish which the cause is and which is effect among these two factors (uric acid and diabetic nephropathy.
Authors and Affiliations
Usha Sachidananda Adiga, BN Malawadi
Keywords
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