Uric Acid Levels in Serum in the Assessment of some Psychiatric Disorders in India

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Uric Acid Levels in Serum in the Assessment of some Psychiatric Disorders in India

Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 1

Abstract

Background: The increasing number of latent and manifest hyperuricemia is important concerning differential diagnosis in neurological and psychiatric diseases. The pathological importance of hyperuricemia in these diseases is particularly unknown. Previous studies have shown that uric acid estimation in cerebrospinal fluid was made with neurological and psychiatric diseases. Monitoring serum uric acid levels, a relatively inexpensive and easily available test, may prove to be a useful adjunct in the assessment of certain indices of certain psychiatric illness. Tranquilizers like 1,4 - benzodiazepine (purinergic) are shown to decrease xanthine oxidase activity initially and may cause fluctuations in serum uric acid levels. Objective: In the present study an attempt was made to understand the effect of tranquilizers on serum uric acid levels in different psychiatric conditions. Methods: 40 cases (22 males and 18 females) of MDP (Maniac depressive psychosis) and Schizophrenia who were undergoing treatment with different tranquilizers from the psychiatric hospital, Patna, India and 20 healthy controls (12 males and 8 females) not using any tranquilizers were included in the study. Results: The serum uric acid levels were significantly elevated (p < 0.05) in these patients receiving treatment with tranquilizers. The levels of uric acid in male patients were significantly higher when compared with females and also over male controls (p < 0.01).In female patients uric acids levels are raised but not significant (p > 0.05) over control females. Conclusion: This preliminary study does indicate that serum uric acid levels do change with the administration of these drugs. The nature, gender, duration and the type of drugs used and their individual effects on different psychiatric disorders will be discussed

Authors and Affiliations

Dr. Syed Saif Subhani

Keywords

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EP ID EP208970
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