URINARY IL-33 AND GALECTIN-3 INCREASES IN PATIENTS WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME
Journal Title: Journal of Medical Biomedical and Applied Sciences - Year 2018, Vol 6, Issue 3
Abstract
Introduction & Objectives: IC/PBS may be mediated by an abnormal immune profile. Uncontrolled and excessive release of alarmins may contributes in the immune dysregulation duringIC/PBS. High mobility group box1 (HMGB1) proteins can participated in pathogenesis of IC/BPC and thus, their analysis in urine of IC/BPC patients may be informative. Materials & Methods: 43 woman with IC/BPS and 29 women as normal controls were enrolled in this study.. Urinary HMGB1 and EGF concentration was determined . All samples were run in triplicate, and urinary EGF and HMGB1 levels without a consistent value in three measures were repeated and the values were averaged. Results:Urinary EGF concentration in IC/BPS patients increased significantly as compared to asymptomatic controls, whether expressed as concentration or the amount relative to urine creatinine in each specimen. Conclusions: Findings indicate that complex changes in the levels of urine HMGB1 are associated with IC/BPS and this group of alarmin may be involved in progression and complications of disease.
Authors and Affiliations
Kochiashvili G Kochiashvili D
Keywords
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- EP ID EP313971
- DOI 10.15520/jmbas.v6i3.98
- Views 42
- Downloads 0
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