URINARY IL-33 AND GALECTIN-3 INCREASES IN PATIENTS WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME
Journal Title: Journal of Medical Biomedical and Applied Sciences - Year 2018, Vol 6, Issue 3
Abstract
Introduction & Objectives: IC/PBS may be mediated by an abnormal immune profile. Uncontrolled and excessive release of alarmins may contributes in the immune dysregulation duringIC/PBS. High mobility group box1 (HMGB1) proteins can participated in pathogenesis of IC/BPC and thus, their analysis in urine of IC/BPC patients may be informative. Materials & Methods: 43 woman with IC/BPS and 29 women as normal controls were enrolled in this study.. Urinary HMGB1 and EGF concentration was determined . All samples were run in triplicate, and urinary EGF and HMGB1 levels without a consistent value in three measures were repeated and the values were averaged. Results:Urinary EGF concentration in IC/BPS patients increased significantly as compared to asymptomatic controls, whether expressed as concentration or the amount relative to urine creatinine in each specimen. Conclusions: Findings indicate that complex changes in the levels of urine HMGB1 are associated with IC/BPS and this group of alarmin may be involved in progression and complications of disease.
Authors and Affiliations
Kochiashvili G Kochiashvili D
Keywords
Related Articles
- EP ID EP313971
- DOI 10.15520/jmbas.v6i3.98
- Views 65
- Downloads 0
Does Planter Pressure Distribution Alter with Weight Reduction in Obese Children?
Background: High plantar pressure values in obese children are of great concern due to the risk of inducing pain, discomfort, and foot pathologies, mainly for children’s growing feet. Obese children have been observed to...
Tuberculosis Treatment Outcome at Becho Health Center, Oromia Region, Ilubabor zone, Ethiopia
Background: Tuberculosis (TB) is a serious public health problem in the developing countries. Early diagnosis, effective treatment and continues assessment of treatment outcome are important indicators of TB control. Thu...
Bleeding feature in the Hematology department in Brazzaville, Congo
Background: Epidemiological and clinical characteristics data of patients with bleeding symptoms are unknown. Methods: a total of 6961 medical records of patients admitted in the hematology department in a teaching hospi...
Suberoylanilide Hydroxamic Acid (SAHA) with Antioxidant vitamin E: Induces ER Stress Pathway in Human Cervical Cancer Cell Line
Suberoylanilide hydroxamic acid (SAHA) is a targeted inhibitor of histone deacetylase, which has been reported to inhibit cell growth, induce apoptosis in a variety of tumor cells and shown to be an anti-cancer agent. Th...
TYPE 1 NEUROFIBROMATOSIS AND EFFECTS ON THE STOMATOGNATIC SYSTEM
Abstract: Neurofibromatosis is a systemic hereditary disorder that mainly affects the skin and nervous system. It was identified for the first time by Friedrich Von Recklinghausen, being called the Von Recklinghausen syn...