Urine total glutathione levels as a potential marker of increased oxidative stress in autism
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2016, Vol 3, Issue 8
Abstract
Objective: Glutathione supplement has been prescribed as a therapy in autism often without proper glutathione quantification in the body. Though, increased speech and increased imaginary play is reported, increased screaming and loosening of stools have been reported as side effects. In this scenario, for an effective management of glutathione administration, we suggest a simple and reliable means of glutathione quantification before its administration. This study pertains to the quantification of total glutathione in autistic children using noninvasively taken urine as sample. Materials & Methods: Urine samples were collected from ten autistic and nine neurotypical children of similar age and sex. Total glutathione was quantified using enzymatic recycling method. Results: Mean levels of total glutathione in autistic children were significantly lower than the neurotypical children (p-value <0.001). Conclusion: We conclude that total glutathione is lower in autistic children and noninvasively collected urine can be used for glutathione quantification before administering glutathione as a therapeutic measure.
Authors and Affiliations
Mini John, Joby Pulikkan, Ranjisha K R, Varsha K S, Midhula Gireesh, Tony Grace
Keywords
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- EP ID EP226013
- DOI 10.17511
- Views 207
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