USAGE OF SUGAR ESTER IN THE PREPARATION OF AVOCADO OIL NANOEMULSION
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
ABSTRACTObjectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology arebecoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllabledroplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal,vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitablenanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits.Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NEwere self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using threedifferent types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4°C, 25°C,and 40°C) for 6 months.Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum dropletsize 106 ± 1.70 nm, size distribution 0.156 ± 0.01, and zeta potential −30.4 ± 0.70. The NE formulations were very stable at 4°C compared to 25°C and40°C while at 25°C NE showed moderate stability, but it was unstable at 40°C.Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4°C.Keywords: Avocado oil, Nanoemulsions, Self-nanoemulsification, Phase inversion technique, Sucrose ester, Stability.
Authors and Affiliations
Nagib A. Elmarzugi, Ahmad M. Eid, Nabil S. Elnattah, Assad A. Elmahgoubi, Mariani Abdul Hamid, Rosnani Hasham, Azila Aziz, Farah Diana Ariffin, Mohamed Salama
Keywords
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