USE OF BACTERIAL LYSATES IN SUBJECTIVE IMPROVEMENT OF CLINICAL RESPONSE IN ALLERGIC RHINITIS PATIENTS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 46
Abstract
BACKGROUND Allergic rhinitis is known to be one of the most common chronic diseases in the world. In this study, we provide an overview of allergic rhinitis responding to immunostimulating agents. According to the concept that allergic rhinitis patients generally suffer from an immune deficit in order to stimulate their immune system specifically or nonspecifically, immunomodulating agents from various sources such as synthetic compounds, tissue extracts or a mixture of bacterial extracts have been used. MATERIALS AND METHODS The aim of the present trial is to evaluate the efficacy of the treatment with an immunostimulating agent consisting of a freeze dried bacterial lysates (Ismigen) and analyse the improvement in clinical response in allergic rhinitis patients. 50 allergic rhinitis patients were enrolled. For all patients, after 3 months of PMBL (polyvalent mechanical bacterial lysates) treatment clinical response was analysed. RESULTS A clinical improvement in subjective symptoms was observed in 43 of the 50 patients treated with bacterial lysates (85.6%). The results are as follows- 45 patients (91.8%), we noticed a decrease in symptoms of nasal blockage and 38 patients (90.4%) were relieved from rhinorrhea; purulent nasal discharge was reduced in 13 cases (81.5%), 30 patients (90.9%) had a large improvement in nasal/palate itching and 15 patients (75%) with headache were relieved. CONCLUSION From this study, bacterial lysates have shown to have a protective effect, which induces a significant reduction of the symptoms and duration related to allergic rhinitis. No negative side effects or worsening of the symptoms have been observed with this medication.
Authors and Affiliations
Vineel Muppidi, Sudeep Madisetti, Lingaiah Jadi, Kalicheti Prabhakar Reddy, Madasani Anunya Reddy
Keywords
Related Articles
- EP ID EP220005
- DOI 10.18410/jebmh/2017/555
- Views 72
- Downloads 0
A COMPARATIVE STUDY BETWEEN MUPIROCIN AND MAGSULPH-GLYCERINE WICK TREATMENT IN THE MANAGEMENT OF ACUTE OTITIS EXTERNA
BACKGROUND Acute otitis externa is a common clinical condition seen in ENT out-patient clinic. It presents with ear pain, itching, otorrhoea, oedema or a stuffy feeling in the ear and can be localized or diffused inflamm...
A SIX YEAR DRUG UTILIZATION STUDY IN A TERTIARY HEALTHCARE SYSTEM: EMERGENCE OF NEWER ORAL ANTICOAGULANTS
BACKGROUND Vitamin K antagonists like warfarin have been used extensively for various medical and surgical conditions. Their use is often associated with bleeding as an adverse effect. Novel oral anticoagulants like dabi...
HIGH CLINICAL SUSPICION IS REQUIRED TO DIAGNOSE HYPER PARATHYROIDISM
INTRODUCTION Patients with primary hyperparathyroidism (elevated parathyroid hormone-PTH) generally have nonspecific complaints. The calcium levels may be normal. Due to these vague complaints, patient diagnosis is often...
PATTERN OF ACUTE CHILDHOOD POISONING – A RETROSPECTIVE STUDY IN ABHA CITY
BACKGROUND Childhood poisoning is a major cause of morbidity and mortality in both developing and developed countries. The objectives of the study are to assess the pattern, causes, frequency and formulate measures to in...
A STUDY ON TIBIAL TORSION IN ADULT DRY TIBIA OF EAST AND SOUTH INDIAN POPULATION
BACKGROUND Rotational deformities of the lower limbs are very common. There is increasing evidence that abnormal torsion in the tibia is associated with severe knee and ankle arthritis. Primary knee osteoarthritis is a l...