USE OF FIXED DOSE COMBINATIONS OF ANTIBIOTICS IN A SURGICAL DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: To study the prescribing pattern and to assess the rationality of fixed dose combinations of antibiotics in surgical department of a tertiary care teaching hospital.Methods: A cross-sectional prospective study was carried out in four inpatients departments (Surgery, Orthopaedics, ENT, Obstetrics & Gynaecology) of a 550-bed tertiary care teaching hospital. Total 100 inpatients data from all four surgical departments were evaluated for prescribing pattern of fixed dose combinations of antibiotics. Data were also assessed for demographic information like number of single formulations of antibiotics used & fixed dose combinations other than antibiotics.Results: Among four departments, FDCs were prescribed as the highest percentage (20.35%) in the surgery department out of all prescriptions. Maximum median duration of stay was nine days in Orthopaedics. Amoxicillin+Clavulanic acid was the most common FDC prescribed out of all antimicrobials in three departments except orthopaedics. O &G department had maximum percentage (45%) of prescription of Clotrimazole+Tinidazole+Clindamycin, whereas this combination was not prescribed by any of other three departments. Cefoperazone+Sulbactam FDCs were maximally prescribed by surgery department (30.43%) followed by orthopaedics. Diclofenac+Paracetamol and Folic acid combinations were the most commonly prescribed FDC’s other than antimicrobials among the subjects.Conclusion: It was observed that the hospital physicians prescribed antibiotics more rationally with no banned drugs and very few new drugs. Rational prescribing of antibiotics would help avoid polypharmacy and prevent drug resistances.Â
Authors and Affiliations
Alpa Pragnesh Gor, Ankush Ajbani, Krunal Dalal
Keywords
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