Use of loading dose of magnesium sulphate versus standard regime for prophylaxis of severe Pre-Eclampsia- A comparative study
Journal Title: International Journal of Clinical Obstetrics and Gynaecology - Year 2017, Vol 1, Issue 2
Abstract
Background: Preeclampsia is a pregnancy specific multi organ disease process characterized by de novo development of hypertension and proteinuria after 20 weeks of gestation. Preeclampsia complicates 2-8% of pregnancies. Present study is carried out to determine the efficacy and safety of only loading dose of magnesium sulphate versus the standard regime in the patients of severe preeclampsia. Materials and Methods: Severe preeclampsia patients were randomly categorised into Group-A (control group) (n=50) and Group-B (study group) (n=50). Patients in the study group received only the loading dose of magnesium sulphate and in the control group the loading dose of magnesium sulphate followed by the maintenance dose every four hourly. Patients in both the groups were monitored closely after the initiation of therapy. Results obtained were statistically analyzed. Results: The mean age of the patients was respectively 24.3 years and 24.60 years. It was observed that most of the patients were primigravidas. In regard to their gestation age, the majority were of term gestation with mean gestation age between 37-40 weeks in both the groups. Out of 50 patients who received prophylactic dose nobody had convulsions whereas 2 patients had convulsions in the group who didn’t receive. There was significant difference of knee jerk and oliguria among patients receiving Modified Pritchard’s and Loading dose only. 8 babies were admitted in NICU who had received injection magnesium sulphate whereas 13 babies had NICU admission in those who didn’t receive the injection. There was no significant difference in the maternal and perinatal outcome in the study. Conclusion: Loading dose of magnesium sulphate is an efficient prophylactic in preventing convulsion in severe preeclampsia patients
Authors and Affiliations
Anima Prasad, Amrish Kumar
Keywords
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