Use of Molecular Diagnostic Test in new AFB Smear Positive Tuberculosis Isolates to Study Multidrug Resistance in Sub Himalayan Region of North India-A Pilot Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Background: Tuberculosis (TB) is the leading cause of morbidity and mortality in India especially in rural areas. Objective: The goal of this study was to examine the patterns of TB drug resistance among new smar positive TB patients in a rural regions of Uttarakhand. Method: All smear positive isolates received under a DOTS centre were stocked. Isolates were subjected to first-line drug susceptibility testing by the Genotype MDR Line probe assay. Results: The prevalence of resistance to any TB drug was 13.6% (38 cases). Eleven percent of the new treatment TB group (28 patients) and 40.7% of the retreatment TB group (11 patients) were resistant to all TB drugs. Twelve (4.3%) patients had multidrug-resistant tuberculosis (MDR-TB) (2.38% in the new TB treatment group and 23.1% in the retreatment group). One patient had extensively drug-resistant tuberculosis (XDR-TB). There was a statistically significant relationship between TB drug resistance and smoking (p=0.02) and a history of migration from village to city (p=0.04), also between TB drug resistance and recurrence of TB in patients that had previously received treatment (p<0.001). Conclusion: Knowledge of drug resistance patterns for new and previously treated cases is critical for effective control of MDR-TB in different regions of the country. The burden of MDR-TB in retreatment cases was high. Previous TB treatment was one of the most important mokers and those who had a history of rural to urban migration were at high risk for the occurrence of TB drug resistance.
Authors and Affiliations
Prachi Jain
Keywords
Related Articles
- EP ID EP285460
- DOI -
- Views 48
- Downloads 0
ECG Signal Conditioning
This paper presents the designing of real time ECG signal conditioning circuit. For designing the real time ECG signal conditioning circuit need to understand the physiology of heart. For analysis the heart activity a in...
A Rare Case of Midgut Volvulus in a 14 Yr Young Girl
Intestinal malrotation is diagnosed in the first month. After birth for the great majority of patients. The incidence of malrotation in adulthood is 0.2%. A 14-year girl presented to our emergency department with c/o bil...
Isolated Primary Hydatid Cyst of Breast: A Case Report and Preoperative Diagnosis
Hyadid cyst of breast is rare disease even in endemic areas. The causative agent is Echinococcus granulosis and Echinococcus multilocularis (Echinococcus alveolaris). Humans are accidental intermediate host of this organ...
Management of Diabetic Foot: A Short Term Analysis in a Tertiary Care Hospital
The diabetic foot is mainly due to 1. Neuropathy 2. Ischemia 3. Infection The study was carried out from 28/07/2014 to 27/07/2015. The new procedure of Irrigation and dressing was done in 80 patients.
Correlation between Epworth Sleepiness Score and Polysomnographic Indices in Sleep Related Breathing Disorders
Background: Sleep disordered breathing is a common disorder affecting the general population carrying significant functional and physiological consequences. Excessive daytime sleepiness (EDS) is a cardinal symptom of Obs...