Use of Recombinant TSH in the Treatment and Monitoring of Well-Differentiated Thyroid Cancers
Journal Title: Nuclear Medicine Seminars - Year 2021, Vol 7, Issue 1
Abstract
Differentiated thyroid cancer (DTC) is an endocrine tumour with mostly good prognosis that requires life long followup. Primary treatments are total thyroidectomy (TT) and radioactive iodine (RAI) therapy. Complete removal of thyroid tissue with TT and RAI causes serum thyroglobuline (Tg) levels to fall to undetectable levels. Thyroid stimulating hormone (TSH) levels have an important role both in preparation for RAI and detection of disease status with stimulated Tg levels in the follow-up. Recently, recombinant human TSH (rhTSH) usage has been incorporated to our clinical practice in I-131 whole body scintigraphy and/or measurement of serum Tg levels and in preparation for RAI ablation. In this review, clinical applications of rhTSH in the therapy and follow-up of DTC will be focused on.
Authors and Affiliations
Elgin Özkan, Mine Araz
Keywords
Related Articles
- EP ID EP693444
- DOI 10.4274/nts.galenos.2021.0010
- Views 82
- Downloads 0
The Role of Thyroglobulin in the Management of Thyroid Cancers
Thyroglobulin (Tg), a glycoprotein that is synthesized in normal thyroid, is a significant biochemical marker of residual thyroid tissue or recurrent/metastatic disease in differentiated thyroid cancers (DTC). In this ma...
Myocardial Perfusion SPECT Procedure Guideline
After Turkish Society of Nuclear Medicine “Cardiology Group” had first published “Nuclear Cardiology Practice Guidelines” in 2001, in line particular with the technological developments, significant changes both in the h...
Oncologic Approaches for Bone Metastasis Related Pain
Bone is the third most common metastatic site after lungs and liver in advanced stages of cancer. Bone pain may be caused by local compression and/or invasion of the tumor or a pathological fracture due to bone metastasi...
Nuclear Medicine Procedures in Diagnosis of Infective Endocarditis
Infective endocarditis (IE) is described as infection of endocardial surfaces of heart and if available prosthesis materials. Despite all up to date developments in diagnosis and treatment of its, IE is mortal and morbid...
Good Radiopharmacy Practices In Magistral (or Inhouse or Smallscale) Produced Radiopharmaceuticals
Radiopharmaceuticals differ from normal medicines in that they have a short half-life. Due to the rapid decay, they must be prepared shortly before their clinical use and comprehensive quality control of the final produc...