Use & Significance of Anti CCP in RA & Seronegative RF Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 9
Abstract
Rheumatoid Arthritis (RA) is the most common systemic inflammatory, auto immune Rheumatic disease. Although the precise aetiology of RA remains unknown1 , there is strong evidence for autoimmunity, 6 The aim of the present study is to evaluate the use and significance of Anti CCP antibodies in Rheumatoid Arthritis with RF positive & in RF Sero Negative Rheumatoid Arthritis(early synovitis) and the Healthy Blood Donors as control. In this study a total number of 150 patients (each group50) including both males and females were studied. Anti-CCP was positive in 39 of 50 RA patients (78%), 14 of 50 (28%) Early Synovitis cases & no HBD were positive for Anti CCP. RF was positive in38 of 50 RA patients, 21 of 50 ES patients & 4 of 50 healthy blood donors. Sensitivity of RF Test in RA is 76% & Specificity is 92%. Sensitivity of Anti CCP test in RA is 78% & Specificity is 100%. Anti CCP Test in Sero Negative RA patients (6 out of 12) is 50%. Being a specific marker in advanced RA, the Anti CCP antibody in ES is a very important predictor. So Anti CCP has the hallmark of establishing as a diagnostic tool, early predictor and provides additive sensitivity to RF. The presence of both in serum is a strong indicator of RA. So it should also be included among the diagnostic criteria of RA along with RF. and as a prognostic indicator in RA patients on treatment.
Authors and Affiliations
Dr P. Shanmugapriya
Keywords
Related Articles
- EP ID EP526374
- DOI -
- Views 77
- Downloads 0
Umbilical-Urachus Sinus A variant of Patent Urachus Presentation With Management in Adults- A single Center Experience
The urachus is located pre-peritoneally in the center of a pyramid-shaped space. This space lies with its base on the anterior dome of the bladder and the tip directed toward the umbilicus. The urachal length varies from...
Assessment of Retention of Skills with Simulator based Training among Anaesthesiology Residents
Background and Aims: A continuing attempt in graduate education is to devise more effective methods to assess and train the residents. Life sized simulators are nowadays being used as a novel technique for this purpose ....
Assessment of QTc Dispersion in Psoriasis Patients: A Case Control Study
Background: Multiple studies demonstrated the association between psoriasis and cardiovascular diseases. QT dispersion (QTD) can be employed to evaluate the cardiac repolarization homogeneity and might be a risk for vent...
Influence of Yoga on Audiovisual Reaction Time of Medical Students
Aim: The present study is to assess the alteration in auditory and visual reaction time, which is an index of central nervous system processing, among medical students. Materials and Methods: Eighty healthy volunteers we...
Serum Creatine Kinase Levels in Overt and Subclinical Hypothyroidism
Introduction: Aim of present study is to assess the relationship between thyroid function and creatine kinase in patients with overt and subclinical hypothyroidism and correlation with thyroid hormone levels. Methodology...