Usefulness of an IV Dose to Attenuate the Haemodynamic Response to Extubation
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 3
Abstract
Aim: Consistent and reliable protection against rise of heart rate and blood pressure during extubation has been aimed at by using propofol in this study. Materials and Methods: It was studied in 50 patients of ASA Grade I & II between age groups 20 - 46 years. 25 patients of comparable age, weight and ASA status were taken as control. Premedication was by glycopyrrolate 0.2 mg 30 minutes prior to induction of anaesthesia. Anaesthesia induced with thiopentone sodium 5 mg/ kg intubation was performed with suxamethonium and maintained with 0 2 and N 2 O with vecuronium as a muscle relaxant, pethidine 1 mg/kg. Patients belonging to the study groups received bolus doses of either 1 mg/kg of lignocaine or 0.5 mg/kg of propofol two minutes prior to extubation. Results: Haemodynamic parameters like Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure, Heart rate were recorded at the following intervals. At induction, at the end of surgery, injection of study drug, 2 minutes after injection of study drug, at extubation, 1 minute after extubation, 2 minutes after extubation and 5 minutes after extubation. Patients who did not receive either of the study drugs showed a significant rise in all the haemodynamic parameters at extubation. In patients who received either of the study drugs the increase in haemodynamic variables were significantly less, thus attenuating the haemodynmic response. No side effects were noted with propofol. Conclusions: It establishes the usefulness of an intravenous bolus dose of propofol 0.5 mg/kg to attenuate the haemodynamic response to extubation. Propofol 0.5 mg/kg is superior to lignocaine 1 mg/kg in prophylaxis of extubation response.
Authors and Affiliations
R. Pandu Naik
Keywords
Related Articles
- EP ID EP471500
- DOI 10.21088/ijaa.2349.8471.4317.6
- Views 77
- Downloads 0
A Comparative Study of Dexmedetomidine HCL and Esmolol HCL for Attenuating Pressor Response to Laryngoscopy and Oral Endotracheal Intubation
Introduction: Laryngoscopy and intubation increases sympathetic activity resulting in tachycardia and hypertension which may cause myocardial ischemia, cardiac arrhythmias and cerebrovascular hemorrhage. We compared the...
Comparative Study of Prevention of Hypothermia Using Preoperative as well as Intraoperative Forced Air Warming with Only Intraoperative Warming in Patients of Surgeries Under General Anaesthesia
Background: Peri-operative hypothermia is very common and associated with many complications. Hypotheremia is most evident in first two hours due to redistribution of heat after induction of general anaesthesia. The stud...
Evaluation of Pre-emptive Intramuscular Glycopyrrolate in Prevention of Spinal Anesthesia Induced Hypotension in Elective Cesarean Sections
Context: Spinal anesthesia induced hypotension in parturients undergoing Cesarean section can be detrimental to both foetus and mother. Prophylactic administration of vasopressors helps in preventing hypotension thereby...
A Prospective Comparative Study of 0.5% Levobupivacaine versus 0.5% Ropivacaine in Supraclavicular Brachial Plexus Block
Background: Levobupivacaine is a s enantiomer of bupivacaine has been introduced in clinical practise in India, with lower cardio toxicity and neurotoxicity in comparison to bupivacaine [7,8]. We have designed present st...
Effect of Dexmedetomidine in Attenuating Hemodynamic Responses During Extubation
ntroduction: Tracheal extubation produces unfavourable hemodynamic alterations which may result in life threatening. The present study was aimed to assess the effect of injection dexmedetomidine 0.5 µg/kg for attenuation...