Ustekinumab successfully treated a patient with severe psoriasis vulgaris with primary failure to infliximab and secondary failure to adalimumab
Journal Title: Nasza Dermatologia Online - Year 2015, Vol 6, Issue 2
Abstract
Biologic drugs have been recently used to treat psoriasis. However, some patients do not respond or lose therapeutic benefit with first-line use of tumor necrosis factor (TNF) antagonists. We report a case of psoriasis vulgaris, that failed to respond to TNF antagonists, infliximab and adalimumab, completely disappeared after treatment with ustekinumab, a therapeutic agent for biologically blocking p40 protein of interleukin (IL) 12 and 23. This report highlights anti-TNF agents only inhibited the TNF-α/inducible nitric oxide synthase (iNOS)-producing dendritic cells (TIP-DCs), but the plasmacytoid-DC-derived psoriatic response was re-initiated. On the other hand, ustekinumab may inhibit both the TIP-DCs and the plasmacytoid-DC-derived inflammatory response
Authors and Affiliations
Chiharu Tateishi,, Kulsupa Nimmannitya, Hisayoshi Imanishi, Daisuke Tsuruta
Keywords
Related Articles
- EP ID EP132610
- DOI 10.7241/ourd.20153.79
- Views 69
- Downloads 0
Maladie de Rosaï-Dorfman a presentation cutanee tumorale
Rosai-Dorfmann disease manifests on the skin commonly as papules, nodules or rarely as infiltrated plaques. Authors report the case of a 27 year-old-man, presenting diffuse, budding and pediculated tumoral skin lesions a...
Herpes Zoster Ophthalmicus: Clinical Profile in Adults less than 30 years of age
Introduction: To establish the clinical profile of Herpes Zoster Ophthalmicus (HZO) in individuals less than 30 years of age and to correlate clinical manifestation with their immune status. Materials and methods: A retr...
Atopic dermatitis in children: Epidemiological and clinical aspects in Côte d'Ivoire
Few studies have been devoted to atopic dermatitis in children in sub-Saharan Africa. We therefore make this study in Côte d’Ivoire in order to contribute to a better knowledge of atopic dermatitis in children on black s...
Lipschütz ulcer: a rare diagnosis to keep in mind
Lipschütz ulcer (LU) is a rare condition that usually affects prepubertal and pubertal girls. It can be misdiagnosed as a sexually transmitted disease or even as a sign of child abuse, causing great anxiety to patients a...
Painful bruising syndrome: A case report
Painful bruising syndrome or Gardner-Diamond syndrome is characterized by an auto erythrocyte sensitization syndrome. We report, here a new case of painful bruising syndrome in a woman with no psychiatric disorders. A 29...