Uterine sarcoma – A retrospective analysis of 19 years experience from a tertiary care centre in south India
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Aim: Retrospective analysis of uterine sarcomas to identify the histological type , prognostic factors, adjuvant treatment and their outcome. Materials and Methods: From 1991 to 2009, 55 uterine sarcomas were treated in the Department of Medical Oncology at Institute of Obstetrics and Gynecology Chennai. This series consists of 27(49% ) malignant mixed mullerian tumors (MMMT) , 16( 29%) leiomyosarcoma (LMS); and 12(22%) endometrial stromal sarcoma (ESS). The median age is in 55years. In 53% of patients ,the presenting symptom was abnormal uterine bleeding .Twenty (36.4%) of patients were in stage I, 4(7.3%) in stage II, 18(32.7%) in stage III and 7 (12.7%) in stage IV according to International Federation of Gynecology and obstetrics(FIGO-1989 ) system. Patients were treated with hysterectomy followed by either chemotherapy or radiotherapy or both. The median follow up period was 17.5 months. Results: Histological type, grade and FIGO stage were identified as the most significant independent prognostic factors in univariate analysis . The median overall survival was 20 months and median disease-free survival was 10.5 months. 5-year survival rate was 38%. Women with low grade ESS were found to have better survival than high grade ESS, MMMT and LMS . Conclusion: The incidence of uterine sarcoma in our hospital was 23.5%(55/234) of uterine malignancies during the study period. The most common histology was malignant mixed mullerian tumors. In comparison to LMS and MMMT , low grade ESS tends to present as a less aggressive disease with favorable outcome. The treatment was mainly hysterectomy, post operative treatment with radiotherapy and chemotherapy had no demonstrable impact on overall survival.
Authors and Affiliations
Dr. P. N. Sathiyamoorthy
Keywords
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- EP ID EP597109
- DOI 10.9790/0853-160503144154.
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