Utility of CBNAAT in diagnosis of mycobacterium tuberculosis in a tertiary care teaching hospital in South India
Journal Title: IP Indian Journal of Immunology and Respiratory Medicine - Year 2018, Vol 3, Issue 1
Abstract
Background Tuberculosis is the ninth leading cause of death worldwide India contributes to about one fifth of global TB burden It is very important to diagnose early and treat Tuberculosis to cut down transmission of TuberculosisMaterial and Methods We conducted a retrospective study in department of Pulmonary medicine to analyze the utility and yield of CBNAAT from Jan Dec 2017 We included all patients who were subjected to CBNAAT in the study period Data was collected from ART centre DOTS centre and CBNAAT centre We collected total number of samples tested for CBNAAT indication for CBNAAT HIV status result of smear microscopy for AFB and CBNAATResults A total of 1703 samples were tested in CBNAAT during the study period Mean age of the study population was 355plusmn102 years 1366 tested were negative and 290 samples were positive for CBNAAT Of these 290 positive samples 267 were sputumBAL samples and 23 were extra pulmonary samples We found rifampicin resistance rate of 24 8329 in pulmonary tuberculosis cases There were no rifampicin resistance detected in extra pulmonary samples CBNAAT could identify 184 cases 133 that were smear negative We found TB HIV coinfection rate of 1002Conclusions We found CBNAAT to be an important diagnostic modality especially in sputum negative patients for early diagnosis and treatment We could detect Mycobacterium tuberculosis in 134 of patients with negative smear for microscopy In PLHIV CBNAAT detected Mycobacterium Tuberculosis in 93 of patients We found rifampicin resistance rate of 24 8329 in pulmonary tuberculosis casesKeywords CBNAAT Tuberculosis Smear negative PLHIV
Authors and Affiliations
Virupakshappa V, Ranganath M, Manjunath M P, Mahendra M
Keywords
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- EP ID EP490630
- DOI 10.18231/2456-012X.2018.0002
- Views 86
- Downloads 0
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