UV Derivative Spectrophotometric Method for Determination of Bisoprolol Fumarate in Bulk and Tablet Formulation
Journal Title: International Research Journal of Pure and Applied Chemistry - Year 2017, Vol 14, Issue 1
Abstract
Simple, cost effective, accurate and reproducible UV derivative-spectrophotometric method were developed and validated for the estimation of bisoprolol fumarate in pharmaceutical preparations. Bisoprolol fumarate was estimated at 233 nm in 50% methanol. The beer’s law was obeyed in the concentration range of 2.0 –10.0 µg/ml (r2 = 0.9995). The apparent molar absorptivity and Sandall’s sensitivity coefficient were found to be 391 L• mol−1•cm−1 and 2.51-g•cm–2 /0.001 respectively, indicating the high sensitivity of the proposed method. The method was tested and validated for various parameters according to ICH guidelines. The detection and quantitation limits were found to be 0.0267 and 0.0808 μg /ml respectively. The proposed methods were successfully applied for the determination of bisoprolol fumarate in pharmaceutical preparations. The results demonstrated that the procedure is accurate, precise and reproducible (R.S.D. < 2%).
Authors and Affiliations
Elsadig H. Rudwan, Amna B. W. E. Mohammed, Ahmed E. M. Saeed
Keywords
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- EP ID EP321252
- DOI 10.9734/IRJPAC/2017/31256
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