Vaccine adverse effects of children hospitalized during 1999 -2009
Journal Title: Polish Journal of Public Health - Year 2013, Vol 123, Issue 1
Abstract
[b]Introduction. [/b]Protective vaccines are linked with the risk of Adverse Events Following Vaccinations (AEFV). In 1991, WHO introduced AEFV supervision. [b]Aim. [/b]The aim of the work was the epidemiological analysis of the medical documentation of all hospitalized children in the Kielce Voivodeship Children’s Hospital with diagnosed AEFV. [b]Material and methods.[/b] The documentation of 29 children who received polyvalent vaccinations and were hospitalized due to AEFV from 1999 to 2009 was analyzed and the results were statistically analyzed. [b]Results. [/b]Medical records of 29 patients hospitalized with a diagnosis of AEFV. It was found that 64 of the vaccine may be the cause of AEFV: 19 were against Polio; 18 followed diphtheria, tetanus, and whole-cell pertussis vaccine (DTP); 10 after Haemophilus influenzae type B; five following each, INFANRIX hexa and DTaP and pneumococcus, hepatitis B virus, rotavirus and measles vaccines. These were second and third doses according to the sequence of administration. It was the following types of AEFV: hypotonic-hyporeactive episode (HHE) and continuous crying in seven, febrile convulsions in six, non-febrile convulsions in four. Seven children presented co-existing diseases after vaccination (pneumonia in two, pharyngitis in two, urinary tract infection in two, and viral gastroenteritis in one child). Recuperation allowed further vaccination. [b]Conclusions.[/b] Polio, DTaP, and Hib vaccines most frequently caused AEFV (HHE, continuous crying, and febrile convulsions). A positive correlation between the number of vaccine components and AEFV frequency was not evident. All children with AEFV were cured without temporary or permanent disqualification from continued vaccinations, while a less reactogenic DTaP vaccine was recommended. We encourage registration of AEFV, even when patients do not require hospitalization.
Authors and Affiliations
Dariusz Skawiński, Sławomir Dutkiewicz, Marian Patrzałek
Keywords
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