Vaccinology: Reflections and the way forward
Journal Title: Journal of Medical and Allied Sciences - Year 2014, Vol 4, Issue 1
Abstract
In recent times vaccine development exploration accelerates the new strategies based on genomics, proteomics, functional genomics and glycochemistry (synthetic chemistry). The evolving Advanced technologies have the potential to identify potential targets (antigens-proteins, cell wall components, polysaccharides), production of genetically engineered proteins (antigenic or carriers) and synthesizing the complex peptidoglycans / lipopolysacchrides. The review primarily focuses on vaccines for bacteria (Mycobacterium tuberculosis); the notorious success of Mycobacterium tuberculosis a highly adapted human pathogen rests intracellular (Latent phase), interferes membrane trafficking in infected macrophages, blocks the process of phagolysosome and thereby protect the pathogen/organism against lysis. The world is witnessing an escalation of multidrug and extreme drug resistant tubercle bacilli challenging the normal therapeutic practices and increased mortality rate. The sequencing of the M. tuberculosis genome has thrown light on newer target proteins that could be used for vaccine development.
Authors and Affiliations
Anubrolu Naveen| Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Andhra Pradesh, India, Uday Shanker Araga| Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Andhra Pradesh, India, Mangamoori Lakshmi Narasu| Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Andhra Pradesh, India
Keywords
Related Articles
- EP ID EP12708
- DOI -
- Views 381
- Downloads 28
Speciation and antifungal susceptibility of esophageal candidiasis in cancer patients in a tertiary care hospital in South India
Esophageal candidiasis is the most common opportunistic infection in patients with altered immunity such as HIV infection, cancer patients on chemotherapy and radiotherapy. Neutropenia, irradiation and chemotherapy wi...
Evaluation of antiulcer activity of Boswellia serrata bark extracts using aspirin induced ulcer model in albino rats
The effect of bark extracts of Boswellia serrata (Family Burseraceae) was evaluated in aspirin induced ulceration (200mg/kg) in albino rats. Antiulcer activity was evaluated by measuring ulcer index and percentage of u...
Lobular capillary hemangioma of esophagus mimicking Barrett’s esophagus
A 30 year old male patient presented to the outpatient department of Gastroenterology with complaints of dyspepsia of 6 months duration associated with progressive dysphagia to solids and liquids. There was no noticeab...
Gold in the male reproductive tract of rat: A chronobiological study
In a 24 hour study, 10 adult male albino rats (total=60) were sacrificed at every four hour starting from 00:00 hours. Reproductive tissues – testis, epididymis (caput, corpus, cauda), vas deference, seminal vesicle,...
Panton-Valentine Leukocidin gene positive methicillin resistant Staphylococcus aureus, the community strains causing infections in intensive care unit - High risk of outbreak and preventing strategies
Methicillin resistant Staphylococcus aureus (MRSA) is an important pathogen that causes hospital acquired infections recorded in the intensive care unit (ICU). Most of the MRSA isolates carry mecA gene which is a molec...