Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 6
Abstract
<span>Background: </span><span>Misoprostol has generally shown good efficacy in promoting cervical softness and facilitating hysteroscopic procedures.<br /> </span><span>Objective: </span><span>To evaluate the efficacy and safety of vaginal misoprostol for cervical priming before diagnostic outpatient hysteroscopy (OH) without anesthesia.<br /> </span><span>Patients and Methods: </span><span>Design: Double-blind randomized controlled trial. Setting: University teaching hospital. Patient(s): Ninety patients requiring diagnostic OH for investigation of infertility or abnormal uterine bleeding in the reproductive age. Intervention(s): Patients were randomly allocated into two equal groups (n= 45). In group I, 200 mcg misoprostol was inserted into the posterior vaginal fornix 3 hours before OH; in group II (control), 250 mg metronidazole as placebo was inserted into the posterior vaginal fornix by investigator. A rigid 30 4-mm hysteroscope was used in the vaginoscopic technique. Main Outcome Measure(s): Ease of cervical entry (Likert scale), procedural time, patient acceptability (Likert scale), and pain scoring (visual analog scale).<br /> </span><span>Result(s): </span><span>Vaginal misoprostol significantly facilitated the procedure; cervical entry was easier, procedural time was shorter, patient acceptability was higher, and pain scoring was lower in group I compared with group II. Side effects of misoprostol were infrequent, minor, and transient. No complications were reported. </span><span>Conclusion(s): </span><span>The regimen of 200 mcg vaginal misoprostol administered 3 hours before diagnostic OH is a simple, effective, and safe method of cervical priming to facilitate the procedure without anesthesia. </span>
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584208
- DOI 10.12816/ejhm.2018.9785
- Views 108
- Downloads 0
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