VALIDATED HPLC METHOD FOR ESTIMATION OF BALOFLOXACIN IN BULK AND DOSAGE FORM
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Balofloxacin, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Sunfire C18 (4.6×150mm, 5µm) column using a mixture of Methanol: Water (50:50 v/v) as the mobile phase at a flow rate of 0.9ml/min, the detection was carried out at 245nm. The retention time of the Balofloxacin was 2.6 ±0.02min. The method produce linear responses in the concentration range of 35-175µg/ml of Balofloxacin. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Balofloxacin, RP-HPLC, validation.
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