Validation of Russell’s Viper Venom Detoxification Activity of Azadirachta indica through In Silico Method
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Azadirachta indica A. Juss. (neem) is one of the Indian medicinal plants used as antidote to snake venom particularly against viper envenomation. In the present study 335 phytochemicals reported from Azadirachta indica were docked with Daboia russelii venom proteins, basic phospholipase A2 VRV-PL-VIIIa (PDB id 1OXL) and class II anticoagulant phospholipase A2 (PDB id 1VIP) using the tool AutoDock 4.2. To avoid error in lead identification, the top ranked hit molecules (∆Gbind<- 10 kcal/mol) were docked using different docking tools such as SwissDock, PatchDock, iGemDock and Hex. The results were analysed following Dempster Shafer Theory (DST) and also the docked structures were analysed in Ligplot+ . The compound 1-acetyl-7-tigloyl-nimbidinin and 1-senecioyl-3-acetyl vilasinin lactol were identified as the leads against phospholipase A2 VRV-PL-VIIIa and nimbocinolide, 1-cinnamoyl vilasinin lactone and tirucallol were identified as leads against class II anticoagulant phospholipase A2.
Authors and Affiliations
Deepa V. 1, S. Sreekumar, C. K. Biju3
Keywords
Related Articles
- EP ID EP383574
- DOI 10.9790/3008-1102033546
- Views 74
- Downloads 0
Constructing of Phylogenetic Tree for Cortex based on DNA sequences
The Phylogenetic expansion of genus is frequently described as the result of arbitrary transformations and predictable choice, which provides the awareness of phylogenetic trees. The large number of elevated superiority...
Serum Hepcidin Concentration is Elevated during Malaria Infection among Children in Sokoto Nigeria
:Malaria and iron deficiency are major public health problems for children living in sub-Saharan Africa. This study was aimed at evaluating serum hepcidin concentration dynamics during malaria infection among children in...
Identification and Characterization of Some Species of Cyanobacteria, Chlorophyta and BacillariophytaUsing FourierTransform Infrared (FTIR) Spectroscopy
In this study FTIR was used to determine and identify 12 species of freshwater microalgae. Cyanobacteria, Chlorophyta and Bacillarophyta species were cultured in Allen media in batch culture. These algae were collected f...
Evaluation of some Serum cytokine and adipokines profile in Iraqi celiac patients before and after treatment
Celiac disease (CD) is main gastrointestinal disease initiated by an immune reaction to gluten in genetically susceptible people. The objective of this analysis attempted to evaluate the nature as well as effect of syste...
Development And Validation Of A Rp-Hplc Method For Simultaneous Determination Of Cilnidipine And Chlorthalidone In Pure And Pharmaceutical Dosage Form
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Cilnidipine and Chlorthalidone, in its pure form as well as in tablet dosage form. Chromatography w...