Validation of Russell’s Viper Venom Detoxification Activity of Azadirachta indica through In Silico Method
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Azadirachta indica A. Juss. (neem) is one of the Indian medicinal plants used as antidote to snake venom particularly against viper envenomation. In the present study 335 phytochemicals reported from Azadirachta indica were docked with Daboia russelii venom proteins, basic phospholipase A2 VRV-PL-VIIIa (PDB id 1OXL) and class II anticoagulant phospholipase A2 (PDB id 1VIP) using the tool AutoDock 4.2. To avoid error in lead identification, the top ranked hit molecules (∆Gbind<- 10 kcal/mol) were docked using different docking tools such as SwissDock, PatchDock, iGemDock and Hex. The results were analysed following Dempster Shafer Theory (DST) and also the docked structures were analysed in Ligplot+ . The compound 1-acetyl-7-tigloyl-nimbidinin and 1-senecioyl-3-acetyl vilasinin lactol were identified as the leads against phospholipase A2 VRV-PL-VIIIa and nimbocinolide, 1-cinnamoyl vilasinin lactone and tirucallol were identified as leads against class II anticoagulant phospholipase A2.
Authors and Affiliations
Deepa V. 1, S. Sreekumar, C. K. Biju3
Keywords
Related Articles
- EP ID EP383574
- DOI 10.9790/3008-1102033546
- Views 59
- Downloads 0
Prescription Pattern And Potential Drug- Drug Interactions of Patients Hospitalised For Urinary Tract Infection in A Tertiary Care Hospital
Urinary tract infections (UTI) are quite common in the community medical practice. The objective of our study was to know the prescription pattern of drugs used in the treatment of UTI. A retrospective observational stud...
Phytochemical Screening and GC-MS Analysis of Methanolic leaf Extract of an Endemic Plant Kayea assamica.
:Kayea assamica is an endemic plant species of Clusiaceae family found only in Padumoni Park and Dullung Reserved Forest of Lakhimpur district of Assam, India. It has significant ethnopharmacological evidence, but still...
Controlling Mosquito Populations and Reducing the Risk of Mosquito-Borne Diseases in a Beach Resort of Punta Cana Using Eco-Friendly Technologies
A new technology to deliver eco-friendly pesticides was developed in order to control mosquitoes, reduce the threat posed by mosquito-borne diseases, and to greatly reduce the amount of pesticides delivered into the envi...
Studies on Molecular Identification of Anabaena Cyanobionts of Azolla Species
Azolla is a genus of free-floating water fern which is widely distributed in aquatic habitats of the tropics and temperate regions. It is one of few vascular plants known to exhibit a symbiotic association with N2- fixin...
Use of Simplified Prognostic Scoring System to evaluate prognostic factors for the survival in patients with Fournier’s gangrene (FG)
Objectives: to evaluate prognostic factors for the survival in patients with Fournier’s gangrene (FG), and applying a prognostic scoring systems to assess the outcomes of survival. Aim of the study: To evaluate prognosti...