VALIDATION OF URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, INTERLEUKIN-18 AND KIDNEY INJURY MOLOCULE- 1 IN THE DIAGNOSIS OF HEPATORENAL SYNDROME IN EGYPTIAN PATIENTS WITH HEPATITIS C VIRUSRELATED LIVER CIRRHOSIS
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 5
Abstract
Hepatorenal syndrome (HRS) is a functional and potentially reversible form of AKI that occurs in cirrhosis patients with ascites caused by splanchnic vasodilatation , cardiovascular dysfunction and renal hypo-perfusion; all these hemodynamic changes are triggered by portal hypertension. SCr, the clinical standard to dene kidney function, poorly discriminates AKI type in cirrhosis so there is urgent need for new biomarkers for early detection and differential diagnosis of AKI in cirrhosis. This study was conducted in the Department of Internal Medicine, Minia University Hospital along the period from January and November . The aim of our study was validate the accuracy of urinary neutrophil gelatinase associated lipocalin (NGAL), interleukin- (IL- ) and kidney injury molecule- (KIM- ) in the diagnosis of HRS in Egyptian patients with hepatitis C virus (HCV) - related liver cirrhosis with serum creatinine as a gold standard test for kidney injury. Conclusions Urinary NGAL, KIM- and IL- are valid biomarkers for detection of AKI in hospitalized cirrhotic patients with AKI The studied urinary biomarkers could not differentiate different subtypes of AKI in cirrhotic patients.
Authors and Affiliations
Shereen Mohammed Mohammed El- Saghir, Mona Abd El- Rahman Abu El- Makarem, Yehia Zakaryia Mahmoud, Hesham Kamal Habeeb Keryakos
Keywords
Related Articles
- EP ID EP598354
- DOI -
- Views 50
- Downloads 0
PREVALENCE OF GOITER AMONG PRIMARY SCHOOL CHILDREN IN DEBRE TABOR TOWN, NORTHWEST ETHIOPIA: A CROSS SECTIONAL MIXED STUDY
Background: There are many explanations for children to underachieve at school such as nutritional, socio cultural, environmental and other factors. Iodine deciency disorder is the major cause of avoidable brain damage...
EXECUTIVE FUNCTIONS AND LEVELS OF STRESS IN DECISION-MAKING: A STUDY OF ADOLESCENTS WITH CLEFT LIP AND PALATE
The objective was to evaluate executive performance in the decision-making process of adolescents with cleft lip and palate. The data were obtained through the neuropsychological evaluation and the Elisa test, through th...
CORRELATION OF CLINICAL SCORE AND SERUM ACETYLCHOLINESTERASE LEVEL, AS A PREDICTOR OF OUTCOME AMONG PATIENTS WITH ACUTE ORGANOPHOSPHATE POISONING ADMITTED IN EMERGENCY WARD OF TERTIARY HOSPITAL IN EASTERN NEPAL
Introduction: Organophosphorus (OP) insecticide self-poisoningis a major clinical and public health problem across much of rural Asia with hundreds of thousands of deaths each year.Owing to the limited availability of fa...
EFFECT OF HELICOBACTER PYLORI RELATED GASTRITIS ON THE RISK OF METABOLIC SYNDROME
Evidence indicates that HP infection is also associated with metabolic syndrome. Specically, a cross-sectional study of a large population of Japanese adults evaluated the concentration of HPspeci c immunoglobulin G (I...
THERAPEUTIC CLONING FROM THE PERSPECTIVE OF PUBLIC LAW
Therapeutic cloning is one of the important branches of the new science of cloning, sub-trends stem cells and eld of genetics. Today, medical and research results of "therapeutic cloning" is debatable from different dim...