VALIDATION OF URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, INTERLEUKIN-18 AND KIDNEY INJURY MOLOCULE- 1 IN THE DIAGNOSIS OF HEPATORENAL SYNDROME IN EGYPTIAN PATIENTS WITH HEPATITIS C VIRUSRELATED LIVER CIRRHOSIS
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 5
Abstract
Hepatorenal syndrome (HRS) is a functional and potentially reversible form of AKI that occurs in cirrhosis patients with ascites caused by splanchnic vasodilatation , cardiovascular dysfunction and renal hypo-perfusion; all these hemodynamic changes are triggered by portal hypertension. SCr, the clinical standard to dene kidney function, poorly discriminates AKI type in cirrhosis so there is urgent need for new biomarkers for early detection and differential diagnosis of AKI in cirrhosis. This study was conducted in the Department of Internal Medicine, Minia University Hospital along the period from January and November . The aim of our study was validate the accuracy of urinary neutrophil gelatinase associated lipocalin (NGAL), interleukin- (IL- ) and kidney injury molecule- (KIM- ) in the diagnosis of HRS in Egyptian patients with hepatitis C virus (HCV) - related liver cirrhosis with serum creatinine as a gold standard test for kidney injury. Conclusions Urinary NGAL, KIM- and IL- are valid biomarkers for detection of AKI in hospitalized cirrhotic patients with AKI The studied urinary biomarkers could not differentiate different subtypes of AKI in cirrhotic patients.
Authors and Affiliations
Shereen Mohammed Mohammed El- Saghir, Mona Abd El- Rahman Abu El- Makarem, Yehia Zakaryia Mahmoud, Hesham Kamal Habeeb Keryakos
Keywords
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