VALIDATION OF URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, INTERLEUKIN-18 AND KIDNEY INJURY MOLOCULE- 1 IN THE DIAGNOSIS OF HEPATORENAL SYNDROME IN EGYPTIAN PATIENTS WITH HEPATITIS C VIRUSRELATED LIVER CIRRHOSIS
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 5
Abstract
Hepatorenal syndrome (HRS) is a functional and potentially reversible form of AKI that occurs in cirrhosis patients with ascites caused by splanchnic vasodilatation , cardiovascular dysfunction and renal hypo-perfusion; all these hemodynamic changes are triggered by portal hypertension. SCr, the clinical standard to dene kidney function, poorly discriminates AKI type in cirrhosis so there is urgent need for new biomarkers for early detection and differential diagnosis of AKI in cirrhosis. This study was conducted in the Department of Internal Medicine, Minia University Hospital along the period from January and November . The aim of our study was validate the accuracy of urinary neutrophil gelatinase associated lipocalin (NGAL), interleukin- (IL- ) and kidney injury molecule- (KIM- ) in the diagnosis of HRS in Egyptian patients with hepatitis C virus (HCV) - related liver cirrhosis with serum creatinine as a gold standard test for kidney injury. Conclusions Urinary NGAL, KIM- and IL- are valid biomarkers for detection of AKI in hospitalized cirrhotic patients with AKI The studied urinary biomarkers could not differentiate different subtypes of AKI in cirrhotic patients.
Authors and Affiliations
Shereen Mohammed Mohammed El- Saghir, Mona Abd El- Rahman Abu El- Makarem, Yehia Zakaryia Mahmoud, Hesham Kamal Habeeb Keryakos
Keywords
Related Articles
- EP ID EP598354
- DOI -
- Views 67
- Downloads 0
TRACHOMATOUS TRICHIASIS (TT) SURGICAL QUALITY OUTCOME AUDIT IN HADIYA ZONE AND YEM SPECIAL DISTRICT, SOUTHERN ETHIOPIA.
Introduction: Trachoma is the leading infectious causes of blindness Worldwide. Trachomatous Trichiasis ( T T ) is a consequence of progression of conjunctival scarring caused by recurrent infection of Chlamydia Trachoma...
ASSESSMENT OF THE IMPACT OF RADIOIODINE THERAPY OF THYROID CANCER IN POSTOPERATIVE CASES USING SCINTIGRAPHY
This study was carried out to assess the Impact of Radioiodine therapy of thyroid cancer in post-operative cases in King Khalid Hospital – Saudi Arabia using scintigraphy, it was a descriptive retrospective, and a prospe...
EFFECT OF EXERCISE ON HEART RATE RECOVERY INDEX IN NORMOTENSIVE OFFSPRING WITH FAMILY HISTORY OF HYPERTENSION
Objectives: The relationship between autonomic system and cardiovascular mortality is signicant and this study can be used to study the hereditary risk that an individual carries to develop any autonomic dysfunction and...
ARTIFICIAL INTELLIGENCE IN BREAST DISEASE MANAGEMENT:NO INNOVATION WITHOUT EVALUATION.
Articial intelligence (AI) in medicine and healthcare has been a particularly hot topic in recent years,such a rapidly progressing, highly innovative subject including not only diagnostic modalities but also interventio...
FACTORS AFFECTING TIME OF SPONTANUOUS DELIVERY OF DICHORIONIC DIAMNIOTIC TWIN PREGNANCY
Twin pregnancies pose a higher risk for intrapartum complications and perinatal morbidity and mortality. As more women delay childbearing and the number of pregnancies conceived with assisted reproductive technology rise...