Valuable Modern Strategy (ATR-IR) Spectroscopy Technique to Distinguish Between Normal and Lung Cancer Tissue
Journal Title: Middle East Journal of Cancer - Year 2019, Vol 10, Issue 1
Abstract
Background: Diagnosis of lung cancer is often delayed because most of the patients are asymptomatic during the primary cancer stages. Infrared spectroscopy is an improved technique compared with the others for identifying abnormal tissue types because of its spatial and spectral capabilities. Therefore, this study is taking an advanced advantage of the physical and optical properties of the attenuated total reflection Fourier-transform infrared system. Methods: The attenuated total reflection Fourier-transform infrared has been applied for cancer detection at infrared wavelengths that range from 4000-400 cm-1. This technique may be a beneficial diagnostic method because it uses the principles of physics, as optics and photonics with a specific wavelength region, which can make an immense difference. Results: The attenuated total reflection Fourier-transform infrared system spectra of normal lung tissue showed main peaks at 3321 and 1637 cm-1, which has been assigned to the OH and C=O function group of amide I and has intensities of approximately 61% (OH) and 76% (C=O). That intensity has been shown to decrease in the cancer tissue. A new peak at 1545 cm-1 appeared in the cancerous tissue, which could be an amide II. Conclusions: The identification of a biochemical component from either normal or cancerous lung tissue would help to evaluate malignant tissue. Thus, the obtained results indicated degradation of the biochemistry component (protein) of the tissue due to carcinogenic disease.
Authors and Affiliations
Ammar Alhasan, Ali Tammar Hussein
Keywords
Related Articles
- EP ID EP443508
- DOI -
- Views 76
- Downloads 0
Sexual Function in Cervical Cancer Survivors after Concurrent Chemoradiotherapy
Background: This study evaluated sexual function in cervical cancer survivors after concurrent chemoradiotherapy. Methods: Study participants comprised survivors of locally advanced cervical cancer (stages IIB-IVA) who...
Can Clinical Presentation and Ultrasonography Predict the Risk of Malignancy in Thyroid Nodules?
Background: Thyroid nodules are frequent occurrences. This study aims to evaluate the risk of malignancy based on the 2015 American Thyroid Association Management: Guidelines for Adult Patients with Thyroid Nodules and D...
PTEN and p53 Gene Expressions in Breast Cancer Specimens and their Clinicopathological Significance
Background: Breast cancer is the second leading cause of cancer death after lung cancer. Discovering molecular biomarkers is necessary for disease management that includes prognosis prediction and preventive treatment. T...
Identification of Three BRCA1/2 Mutations and a Study of the Likelihood of an Association with Certain Characteristics in Syrian Familial Breast Cancer Patients
Background: The main goal of the present study was to investigate BRCA1 and BRCA2 mutations in a number of Syrian familial breast cancer cases. We included 50 early onset invasive breast cancer patients from different Sy...
Global Inequalities in Cervical Cancer Incidence and Mortality
Objective: Cervical cancer (CC) is the third most common cancer in women after breast and colorectal cancers and is one of the leading causes of cancer death among women in the world. The aim this study is associations o...