Value of liver biopsy in the diagnosis and clinical trial of non-alcoholic fatty liver disease
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Non-alcoholic fatty liver disease （NAFLD） constitutes a series of histological lesions characterized by varying degrees of hepatocyte damage， fat accumulation， inflammation， and fibrosis. Currently， liver biopsy is considered the “gold standard” for evaluating the degree of hepatic steatosis， inflammation， and fibrosis， and it also serves as the cornerstone for accurate grading of NAFLD. This article reviews the value and application of liver biopsy in the clinical diagnosis， staging， and clinical trials of NAFLD.
Authors and Affiliations
Qichao GE, Lungen LU
Keywords
Related Articles
- EP ID EP753500
- DOI 10.12449/JCH241124
- Views 22
- Downloads 1
Effect of interleukin-22 on hepatic stellate cell activation and its mechanism
[Objective] To investigate the effect of interleukin-22 （IL-22） on the activation of hepatic stellate cells （HSCs） and its mechanism. [Methods] The human HSC LX-2 cells were selected for the study， and the LX-2 cell...
Effect of Xiayuxue Decoction against renal injury in mice with non-alcoholic fatty liver disease and its mechanism
[Objective] To investigate the effect of non-alcoholic fatty liver disease （NAFLD） induced by high-fat diet （HFD） on the kidneys of mice and the protective effect and mechanism of Xiayuxue Decoction. [Methods] A tota...
Effect of Bacillus licheniformis preparation on hepatic steatosis and intestinal mucosal barrier function in a rat model of nonalcoholic fatty liver disease
[Objective] To investigate the effects of Bacillus licheniformis on liver histopathology and intestinal mucosal barrier function in rats with nonalcoholic fatty liver disease（NAFLD）. [Methods] A total of 30 male Spragu...
Risk factors for death within 30 days after admission in patients with decompensated liver cirrhosis and acute kidney injury and construction of a nomogram model
[Objective] To investigate the predictive factors for death within 30 days after admission in patients with decompensated liver cirrhosis and acute kidney injury （AKI）， and to establish and validate a nomogram predict...
Interpretation of guideline for diagnosis and treatment of liver failure （2024 version）
In 2024， Liver Failure and Artificial Liver Group， Chinese Society of Infectious Diseases， Chinese Medical Association and Chinese Society of Hepatology， Chinese Medical Association updated Guideline for diagnosis an...