Vaptans
Journal Title: BMH Medical Journal - Year 2015, Vol 2, Issue 4
Abstract
There are three receptors for vasopressin (Antidiuretic Hormone) - the V1a, V1b, and V2 receptors. The V2 receptors primarily mediate the antidiuretic response, while V1a and V1b receptors primarily cause vasoconstriction and adrenocorticotropic hormone (ACTH) release, respectively. V2 receptor antagonists, collectively known as Vaptans, competitively block the binding of vasopressin to V2 receptors, which are located on renal collecting duct cells. This prevents Vasopressin-mediated activation of these receptors. These class of agents cause selective water diuresis (aquaresis), and does not cause sodium and potassium loss. These agents by causing aquaresis, helps to raise serum sodium levels.
Authors and Affiliations
Raju A Gopal
Keywords
Related Articles
- EP ID EP324115
- DOI -
- Views 113
- Downloads 0
A Case of ANCA Negative Pauci-immune Crescentic Glomerulonephritis in Mixed Connective Tissue Disease
Pauci-immune crescentic glomerulonephritis (CrGN) is one of the most common causes of rapidly progressive glomerulonephritis. The majority of patients with pauciimmune CrGN have circulating antineutrophil cytoplasmic aut...
MRI Conditional Pacemakers
Conventionally, magnetic resonance [MR] imaging is an absolute contraindication for those with an implanted pacemaker.This represents a significant clinical problem as several studies have shown approximately 75% of pati...
A Rare Tumour With A Rare Presentation
Sarcomatoid variant of urothelial carcinoma is a very rare tumor, and this tumour arising in a ureteric location is even rarer still. We report a case of such a tumor with this rare presentation.
Ebola: Few Thoughts for General Public and Health Care Workers
Ebola virus disease (EVD) outbreak has occurred recently in several African countries. As we are all aware that being a disease which cause high mortality appropriate infection prevention control measures can be implemen...
A Case Of Tracheal Tumor Masquerading As Asthma
There are a variety of disease processes that either masquerade as asthma or contribute to worsening asthma symptoms in patients with asthma. Obstruction in the large airways of the chest commonly presents with expirator...