Variation in Serum Total Testosterone Levels in Men with Type 2 Diabetes Mellitus
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 6
Abstract
ABSTRACT Introduction: Testosterone is a steroidal hormone that plays an important role in the regulation of carbohydrate, protein, lipid metabolism, thereby control insulin sensitivity. An inverse relationship between serum testosterone, insulin resistance and hyperglycaemia has been well documented. Decreased serum testosterone in Type-2-Diabetes Mellitus (T2DM) promotes accumulation of visceral fat, which increases insulin resistance and in turn, leads to progression of Diabetes Mellitus (DM). Aim: To determine variation in serum total testosterone levels in men with T2DM. Materials and Methods: In the present case-control study, 30 T2DM men (aged 35-55 years) were selected from the OPD of Teerthanker Mahaveer College and Research Centre, Moradabad and 30 healthy age matched individuals, were recruited as controls. Fasting Plasma Glucose (FPG) was estimated by Glucose Oxidase Peroxidase (GOD-POD), end point method. HbA1c was measured by particle enhanced immunoturbidimetric test method and serum testosterone by Enzyme Linked Fluorescent Assay (ELFA) using fully automated VIDAS analyser. Various parameters were analysed using Student’s t-test (independent and unpaired) and the coefficient of correlation was calculated using Pearson’s correlation coefficient. p-value <0.05 were considered as statistically significant, and p-value <0.001 as highly significant. Results: In T2DM patients, serum total testosterone was found to be negatively correlated with FPG (r value=-0.496, p=0.005) and HbA1c (r=-0.548, p=0.002). Out of 30 diabetic patients, 13 (43%) patients had lower level of serum total testosterone when compared to the reference range (<3 ng/mL). The serum total testosterone levels were found to be elevated in diabetic patients with FPG≤200 mg/dL or HbA1c≤6.5 in comparison to patients with FPG>200 or HbA1c>6.5 mg/dL, however the differences were not statistically significant. Relatively comparable serum total testosterone levels were found in diabetic patients with duration of DM≤2 years and DM>2 years, thus suggesting that serum total testosterone concentration might be independent of the duration of DM. Conclusion: Testosterone not only plays a prime role in men’s sexual health but also have an influence on glycaemic status of diabetic patients. Assessment of lower serum total testosterone levels can serve as a useful tool for evaluation of prognosis of T2DM. Therefore, all T2DM patients should be screened for androgen levels and testosterone replacement therapy should be considered to improve overall health of diabetic men.
Authors and Affiliations
Jyoti Trivedi, Sangeeta Kapoor, Rahul Arora
Keywords
Related Articles
- EP ID EP604990
- DOI 10.7860/JCDR/2019/40309.12906
- Views 119
- Downloads 0
Attitude of Reproductive Healthcare Providers to Prenatal Diagnosis in a Low Resource Nigerian Setting
Introduction: Prenatal diagnosis comprises all diagnostic modalities aimed at gaining information about the embryo or fetal wellbeing. It enables antenatal care tailored to the individual need(s) of the fetus. Aim: To de...
Treatment of Tongue Thrusting Habit Using Modified Blue Grass Appliance: A Case Report
ABSTRACT Tongue thrusting habit is a major aetiological factor in the development of anterior open bite. Persistence of an infantile swallow during childhood and adolescence leads to a tongue thrusting habit with clinica...
Moving Ball in Left Atrium-Presenting as Recurrent Syncope
ABSTRACT In patients with rheumatic mitral valve stenosis having atrial fibrillation, the “Ball valve thrombus” is an uncommonly encountered complication. A case of 42-year-old male with rheumatic severe mitral stenosis,...
Role of Pulmonary Function Tests in the Assessment of Lung Impairment in Patients with Diffuse Parenchymal Lung Diseases: Association with Clinicoradiological-Histopathological Profile
ABSTRACT Introduction: Diffuse Parenchymal Lung Disease (DPLD) is known to be a common sequela of various lung insults. DPLD is diagnosed by various modalities such as clinical, radiological, lung function and histopatho...
The Effect of Chamomile Flower Essence on Pain Severity after Elective Caesarean Section under Spinal Anaesthesia: A Randomized Clinical Trial
Introduction: Nowadays, herbal essence and aromatherapy are used as a form of complementary medicine and nonpharmacological interventions alongside modern medicine and pharmacological interventions. Aim: To evaluate the...