Variations in Concentration and Distribution of Several Androgen-Dependent and Independent Trace Elements in Nonhyperplastic Prostate Gland Tissue throughout Adulthood
Journal Title: Journal of Andrology & Gynaecology - Year 2016, Vol 4, Issue 1
Abstract
The variation with age of the Br, Fe, Rb, Sr, and Zn concentration in prostatic tissue and the relationship of these trace elements with basic histological structures of nonhyperplastic prostate glands of 65 subjects aged 21-87 years was investigated by an energy-dispersive X-ray fluorescence (EDXRF) and a quantitative morphometric analysis. Mean values ± standard error of the mean (M±SΕΜ) for the concentrations (mg/L) of these trace elements were: Br 7.89±0.93, Fe 22.2±1.2, Rb 3.49±0.18, Sr 0.43±0.08, and Zn 191±16. The significant trend for increase with age in Fe and Zn concentration as well as for increase with age in relative volume of stroma and decrease in relative volume of epithelium was found. Using the Pearson correlation between trace element concentration and morphometric parameters, it was demonstrated that the glandular lumen is a main pool of Sr and Zn accumulation in the normal human prostate, for the age range 21 to 87 years. It was concluded that the Sr and Zn bind tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid. For ages above 40 years conclusive evidence of a disturbance in prostatic intracellular homeostasis of Fe was also shown.
Authors and Affiliations
Vladimir Zaichick
Keywords
Related Articles
- EP ID EP202431
- DOI 10.13188/2332-3442.1000026
- Views 96
- Downloads 0
Molecular Mechanisms Involved in the Transition of Prostate Cancer Cells from Androgen Dependant to Castration Resistant State
Prostate cancer is an internationally important health problem of the man, particularly in developed countries. Currently the main line of treatment for prostatic cancer is based on androgen deprivation. The androgen blo...
Planar Polarity Factors as Potential Tumor Suppressors in the Urogenital Tract
Signaling pathways, which function in defining the shape and interactions between epithelial cells also play a role in maintaining tissue integrity, and can affect the progression of benign hyperplasias and cancers. For...
Pharmacologic Management of Overactive Bladder and Urge Incontinence: A Review of New and Old Treatment Options
Overactive bladder, particularly when accompanied by urinary incontinence, is a medical condition that affects a significant number of patients and drastically impacts quality of life. In the United States alone, the pre...
Sexual health promotion using social networks in Spain
Background: Sexual health promotion is an act of social responsibility that usually centres on delivering practical advice to the general public or to risk populations. The methods for transmitting these recommendations...
Medically Assisted Insemination
Medically assisted procreation is a procedure that is carried out only when the former fertility treatment without success or hopeless, and in order to avoid transmission of serious hereditary diseases to the child with...