VASCULAR ENDOTHELIAL GROWTH FACTOR VEGF G/C 405 AND C/A 2578 GENE POLYMORPHISMS IN CASES WITH PRE-ECLAMPSIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Vascular endothelial growth factor gene plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia (PE). VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels. This study carried on 170 pregnant women. Out of them, 100 cases with PE. Their mean age ± SD was 25.28 ± 4.59 years. Seventy nine (79%) cases had mild PE and 21 (21%) cases had severe PE. The other 70 subjects were clinically healthy pregnant women with complete successful pregnancy and no PE. VEGF C 405 G and C 2578 A polymorphisms were studied using PCR and RFLP. We found that PE among Egyptian women was strongly associated with pre-eclamptic mutations related to VEGF C 405 G and C 2578 A gene polymorphisms. There were statistically significant low frequencies of wild homozygous genotype CC and high frequencies of heterozygous mutant genotypes CG & CA and homozygous mutant genotypes GG & AA in PE cases compared to controls. The frequency of cases carrying the homozygous mutant genotype GG was higher among severe pre-eclamptic cases compared to mild pre-eclamptic cases. In addition, there were statistically significant high frequencies in PE cases compared to controls of mutant G and mutant A alleles.Â
Authors and Affiliations
Adel Z El-sonbati, Rizk A. El-baz, Entsar A. Saad, Abeer S. El-zekred
Keywords
Related Articles
- EP ID EP579450
- DOI -
- Views 65
- Downloads 0
OPTIMIZATION OF PROCESS PARAMETERS FOR THE PRODUCTION OF ANTIBACTERIAL COMPOUND BY A NEWLY ISOLATED NOCARDIA CYRIACIGEORGICA, KD-15 STRAIN FROM KAZIRANGA NATIONAL PARK OF NORTH EAST INDIA
Objective: An attempt has been made to evaluate the optimal cultural conditions for obtaining high yields of bioactive metabolites.Methods: A strain of actinobacteria was isolated from the soil sample of Kaziranga Nation...
FLAVONOID CONTENT AND ANTIBACTERIAL ACTIVITY OF ALBIZIA JULIBRISSIN. DURAZZ LEAF, STEM AND FLOWER EXTRACTS AGAINST CLINICALLY ISOLATED BACTERIAL PATHOGENS
Objective: Â To test the antibacterial efficacy of leaf, stem, and flower extracts of Albizia julibrissin against bacterial pathogens.Methods: Â Extraction of active metabolites was carried out by using six different sol...
PHYTOCHEMICAL SCREENING, GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITY OF CORIANDRUM SATIVUM (L) SEEDS
Objective: The present study was carried out to evaluate the phytochemical screening, Gas Chromatography–Mass Spectrometry analysis of phyto-constituents and antibacterial activity of Coriandrum sativum (L.) seeds agai...
NEPHROPROTECTIVE, NEPHROCURATIVE ACTIVITY OF MIMOSA PUDICA ROOT AGAINST GENTAMICIN INDUCED NEPHROTOXICITY
Objective: To study nephroprotective effect of ethanolic extract of Mimosa pudica root against Gentamicin induced nephrotoxicity in rats. Methods: After the treatment scheduled period of 21 days, the extent of nephrotox...
A SIMPLE AND A CHEAP UV SPECTROPHOTOMETRIC ASSAY METHOD DEVELOPMENT AND VALIDATION OF DABIGATRN ETEXILATE IN CAPSULES
Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Dabigatrn etexilate (150mg) in capsules and validate as per ICH guidelines.Method: The optimized method uses 0.05N...