Vascular permeability- increasing effect of the leaf essential oil of <i>ocimum gratissimum</i> linn as a mechanism for its wound healing property
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 3
Abstract
Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of [i]Ocimum gratissimum[/i] heal wounds by promoting this feature? Evan’s blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan’s blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30µg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p
Authors and Affiliations
Lara Orafidiya, F. Fakoya, E. Agbani
Keywords
Related Articles
- EP ID EP133819
- DOI -
- Views 89
- Downloads 0
ANTIHYPERGLYCEMIC AND RENAL PROTECTIVE ACTIVITIES OF ANACARDIUM OCCIDENTALE (ANACARDIACEAE) LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS.
Earlier studies from our laboratory have indicated hypoglycaemic action of Anacardium occidentale (AO) leaves in experimental type 1 diabetes. Streptozotocin-induced diabetes in rats had been shown to be associated with...
Safety of traditional medicines, complementary and alternative medicines in Africa
Gossypol content on leaves and seeds from some wild <i>malvaceae</i> species
Ten Malvaceae species were analysed for their seed and leaf gossypol content by HPLC. The results showed that gossypol is common in most of the Malvaceae family, but its concentration varies among the species and also am...
Toxicity of erythrophleum guineense stem-bark: role of alkaloidal fraction
The effect of the in vivo administration of the total alkaloidal fractions of the stem-bark of the Erythropleum guineense on certain biological parameters of Sprague-Dawley rats was investigated. The results revealed tha...
EVALUATION OF ANALGESIC, ANTICONVULSANT AND HYPNOTIC ACTIVITIES OF PYRENACANTHIA STAUNDTII
An Aqueous leaf extract of Pyrenacanthia Staundtii (AqPs) was studied for central nervous activities. The extract (100.0 – 400.0 mg/kg i. p). significantly (p