VEGF: A Noble Immunohistochemical Marker in Diagnosis of Dysfunctional Uterine Bleeding
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 3
Abstract
Background: Dysfunctional uterine bleeding (DUB) is characterized by abnormal bleeding that is unrelated to any identifiable cause. The aim of this study is to establish that, DUB is a disorder of angiogenesis by detecting vascular endothelial growth factor (VEGF) expression on immunohistochemistry(IHC) study of DUB endometria. Material and Methods: It was a cross section study, undertaken at Index Medical College, Indore over a period of 18 months from March 2015 to July 2016. The study includes 100 endometrial dilation and curettage (D&C) and hysterectomy specimen of clinically diagnosed DUB patients. These specimens were studied for histopathology and expression of VEGF. Results: VEGF expression in endometria of DUB patients was significantly higher than in endometria of control group. There was also significant higher expression of VEGF in endometrial hyperplasia. Conclusion: Significantly over expression of VEGF in the endometrial glands in cases of DUB suggest that VEGF plays an important role in the pathogenesis of DUB
Authors and Affiliations
Snehil Agrawal
Keywords
Related Articles
- EP ID EP466560
- DOI 10.21088/ijprp.2278.148X.6317.24
- Views 107
- Downloads 0
Skin Adnexal Tumors: An Experience at Tertiary Care Centre
Background: Skin adnexal tumors are large and diverse group of uncommon neoplasms usually misdiagnosed clinically due to their large variety and variants. Histopathology usually helps in establishing the diagnosis. Aims:...
Assessing the Prognostic Importance of ER, PR Expression in Meningiomas by Comparing with Proliferative Rate Using Ki67
Background: Meningiomas are common brain tumors which are mostly benign and recur frequently. These tumors exhibit steroid hormone receptors which are related to the behavior of the tumor. Aim: To conduct a retrospective...
Use of PDCA Cycle in Improving Compliance to Universal Safety Precautions in a Medical College Laboratory
Introduction: We studied effectiveness of PDCA cycle in improving compliance of laboratory staff with respect to universal safety precautions. Material and Methods: We noted compliance of staff to safety precautions like...
A Descriptive Study on Morphological Pattern of Anemia among Patients Attending Tertiary Care Hospital in Chennai
Background: Anemia has a significant health burden in developing nation. Etiology is determined by looking at the morphology of R.B.C which determines the degree of hemoglobinization. Aims and objectives: To determine th...
Spontaneous Bacterial Peritonitis: Diagnostic Importance of Ascitic Fluid Polymorphonuclear Cell Count, Biochemical and Microbiological Analysis
Introduction: Ascites represents the pathological collection of fluid in the peritoneal cavity. Spontaneous bacterial peritonitis is the infection of the ascitic fluid. For its diagnosis, the number of polymorphonuclear...