VEGF: A Noble Immunohistochemical Marker in Diagnosis of Dysfunctional Uterine Bleeding
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 3
Abstract
Background: Dysfunctional uterine bleeding (DUB) is characterized by abnormal bleeding that is unrelated to any identifiable cause. The aim of this study is to establish that, DUB is a disorder of angiogenesis by detecting vascular endothelial growth factor (VEGF) expression on immunohistochemistry(IHC) study of DUB endometria. Material and Methods: It was a cross section study, undertaken at Index Medical College, Indore over a period of 18 months from March 2015 to July 2016. The study includes 100 endometrial dilation and curettage (D&C) and hysterectomy specimen of clinically diagnosed DUB patients. These specimens were studied for histopathology and expression of VEGF. Results: VEGF expression in endometria of DUB patients was significantly higher than in endometria of control group. There was also significant higher expression of VEGF in endometrial hyperplasia. Conclusion: Significantly over expression of VEGF in the endometrial glands in cases of DUB suggest that VEGF plays an important role in the pathogenesis of DUB
Authors and Affiliations
Snehil Agrawal
Keywords
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- EP ID EP466560
- DOI 10.21088/ijprp.2278.148X.6317.24
- Views 89
- Downloads 0
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