Ventilatory response to exercise as an independent predictor of long-term survival in chronic heart failure
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2006, Vol 23, Issue 6
Abstract
OBJECTIVE Patients with chronic heart failure (CHF) present exercise-induced hyperpnea, but the predictive role of this abnormal ventilatory response in risk stratification and its pathophysiological mechanism have not been thoroughly investigated. The objective of this study was to determine the relationship between exercise hyperpnea and resting hemodynamic measurements and evaluate the validity of VE/VCO2 as a risk predictor in patients with CHF. METHOD The study included 90 men and 8 women with CHF, who underwent a symptom-limited treadmill cardiopulmonary exercise test (CPET). Right heart catheterization and radionuclide ventriculography were performed within 72 hours of CPET. The follow-up period was 20±6 months. RESULTS The mean (±SD) left ventricular ejection fraction was 31±12% and the pulmonary capillary wedge pressure (PCWP) was 13.8±7.9 mmHg. Twenty-seven patients died from cardiac causes during follow-up. Non-survivors compared to survivors had a lower peak VO2 (16.5±4.9 vs 20.2±6.1 mL/kg/min, P=0.003), a steeper VE/VCO2 slope (34.8±8.3 vs 28.9±4.8, P
Authors and Affiliations
D. SAKELLARIOU, S. NANAS, O. PAPAZACHOU, P. RODITIS, E. TSOLAKIS, I. VENETSIANAKOS, C. ROUSSOS
Keywords
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