VERAPAMIL - HYDROCHLORIDE AT LOW CONCENTRATIONS INHIBITS THE GROWTH OF RELAPSE GLIOBLASTOMA
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 10
Abstract
The life expectancy of glioblastoma patients was investigated in the distant postoperative period. These patients were treated with such concentrations of verapamil – hydrochloride, that minimize the level of blood cells aggregation in II stage of the inflammatory process. 11 patients received treatment (I group) and 32 patients did not received treatment (II group) with calcium blocker using verapamil – hydrochloride examples in pills. For the objectification of tumor association inflammation (TAI), that present’s in the patient’s body, the definition of blood cells aggregation was examined on the “Plasmon” sensor. Peripheral blood cells were collected from patients to determine the indicators of blood cells aggregation with the addition of various aqueous of verapamil – hydrochloride (from 1: 10 to 1: 100,000 times). Patients took drugs at the lowest level of blood cells aggregation doses. Drug dose was performed by decreasing its concentration by a factor of 10, 000. From the 43 patients, admitted to the clinic, only 3 patients did not undergo chemotherapy at will. After the surgical removal of glioblastoma and the postoperative irradiation course, they only took verapamil – hydrochloride at low concentration daily. In the I group of 8 patients, undergoing combined treatment courses and taking verapamil - hydrochloride, the average life expectancy was 18.6 ± 1.82 months and 8.47 ± 1.02 months in the group of 32 patients (Cox’s F - test p = 0,00108). Three patients without chemotherapy in the postoperative period received daily treatment with verapamil – hydrochloride without interruption for life. All 3 patients continue to live for 19, 25 and 29 months, respectively. The paper presents for the first time the results of highly malignant glioblastoma treatment with low concentrations of the NMDA-dependent calcium blocker verapamil – hydrochloride. The results indicate a high antitumor activity of the drug, both when used together with traditional methods of treatment or separately.
Authors and Affiliations
N. Ya. Gridina
Keywords
Related Articles
- EP ID EP674568
- DOI -
- Views 206
- Downloads 0
ACHYRANTHES ASPERA -A PROMISING MEDICINAL HERB
Achyranthes aspera Linn. (Amaranthaceae family) is an important medicinal plant is found throughout Bangladesh as an annual herb. The medicinal plants are used for treatment of various diseases because of their safety an...
ROLE OF CYTOKINES(INF- Γ, IL-6, IL-10) IN THE PATHOGENESIS OF AUTOIMMUNE TYPE I DIABETES MELLITUS
Type I diabetes mellitus is an autoimmune disease; it is one of most serious and common metabolic disorders in children and adolescents, in which the body immune system destroys the insulin releasing beta cells. Thus, th...
CONTAMINATION OF SOME PUBLIC SCHOOLS’ PREMISES WITH GEOHELMINTHS’ AND TAENIA OVA IN AGO-IWOYE, SOUTH-WESTERN NIGERIA
Fecal contamination of the environment of school children makes them readily exposed to infection and reinfection by soil-transmitted helminths (STHs). Soil samples from the premises of selected four public primary schoo...
KNOWLEDGE AND ATTITUDE OF MOTHERS TOWARDS CHILD ADOPTION PRACTICES IN OGBE AHIARA AHIAZU MBAISE IMO STATE
This study was carried out on the knowledge and attitude of mothers towards child adoption practice in Ogbe Ahiara Ahiazu Mbaise. The objective was to determine the knowledge of child adoption among the mothers in Ogbe A...
NURSING AND RADIOGRAPHY STUDENTS’ PERCEPTIONS OF THEIR LEARNING CLIMATE AT THE SCHOOL OF NURSING, UNIVERSITY OF NAMIBIA
An effective learning climate is described as being humanistic, authentic, supportive and caring. Both the nurse educators and the institution alike therefore have a key responsibility to provide a caring environment tha...