Viral load on Preeclamptic pregnant women with and without periodontal disease and its effect on pregnancy outcomes- A Cross-sectional study.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 6
Abstract
Background: Viral load has its own significance in the pathophysiology of various systemic ailments. Aim of the present study was to quantify the viral load in normal pregnant women and preeclamptic pregnant women with and without periodontal disease and relating the same with pregnancy outcomes. Materials and methods: A Cross-Sectional study is designed on pregnant women with and without periodontal disease and preeclampsia, who are attending Narayana hospital, Nellore for prenatal checkups. 445 women were recruited in the study after obtaining the consents. Based on systemic and periodontal health, subjects were grouped into Group-1 (systemically healthy and periodontally healthy), Group-2 (systemically healthy with periodontal disease), Group-3 (preeclamptic women with periodontal disease) and Group-4 (preeclamptic women without periodontal disease). Clinical parameters like plaque index, bleeding on probing, Probing depth andclinical attachment level were recorded. Quantification of viruses like Ebstein Barr Virus, Herpes Simplex Virus Cytomegalovirus was done in subgingival plaque and placental tissue. Information related to type of newborn delivered (preterm lowbirth weight, normal birth) was obtained and recorded for further comparision. Results: Women with preeclampsia and periodontal disease had more adverse outcomes and expressed more viral load compared to other groups, that is group 4. 2 and 1 respectively in both subgingival plaque and placental tissue samples.Conclusions: There was a significant association between preeclampsia and periodontal diseases with pregnancy outcomes. Viral load has a definite role in the development of preeclampsia, periodontal disease and pregnancy outcomes as well.
Authors and Affiliations
Dr. Jaideep Mahendra
Keywords
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