Virusların duyarlı konak hücreleri enfekte etmek için kullandıkları bazı reseptörler
Journal Title: Antakya Veteriner Bilimleri Dergisi (The Journal of Antakya Veterinary Sciences) - Year 2022, Vol 1, Issue 1
Abstract
Virus-host interactions are crucial in viral pathogenesis and tissue tropism. The interaction between a virus and its host cell begins with the binding of the virus particle to specific receptors on the cell surface. Viral binding proteins that mediate the binding mechanism play an important role. The viral attachment protein can be seen as the "key" that unlocks host cells by interacting with the receptor on the cell surface. These key-lock model interactions are critical to the successful entry of viruses into host cells. Surface glycoproteins, binding pockets that bind to cellular receptors such as canyons, and viral capsid proteins containing extended loops are important parts of the viral attachment mechanism. During this attachment mechanism, multiple interactions occur between the virus and the cell. Viruses use a variety of strategies to bind to one or more receptors, cross the plasma membrane barrier, and enter the host cell. The viral attachment protein can be seen as the "key" that unlocks host cells by interacting with the receptor on the cell surface. These key-lock model interactions are critical to the successful entry of viruses into host cells. It has been determined by studies that viruses target certain classes of molecules while using receptors in infections. Integrins, nectins, and members of the immunoglobulin superfamily are some of the receptors commonly used by viruses. Furthermore, many receptors are awaiting discovery in order to clarify the virus-host interaction mechanisms. The identification of these viral receptors on host cells is one of the most active fields of virology. In this review, it is aimed to reveal which receptors on host cells are used by some virus families, especially those that are prominent in veterinary medicine, in the light of current studies.
Authors and Affiliations
Oğuzhan KAPLAN
Keywords
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- EP ID EP711822
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